Art

J-GLOBAL ID：200902134220632359   Reference number：03A0004670

Synthesis of (-)-TAN1251A using 4-hydroxy-L-proline as a chiral source.

キラル源として4-ヒドロキシ-L-プロリンを用いる(-)-TAN1251Aの合成

Author (8)： NAGUMO S (Hokkaido Coll. Pharmacy, Otaru, JPN) ,  MATOBA A (Hokkaido Coll. Pharmacy, Otaru, JPN) ,  ISHII Y (Hokkaido Coll. Pharmacy, Otaru, JPN) ,  YAMAGUCHI S (Hokkaido Coll. Pharmacy, Otaru, JPN) ,  AKUTSU N (Hokkaido Coll. Pharmacy, Otaru, JPN) ,  NISHIJIMA H (Hokkaido Coll. Pharmacy, Otaru, JPN) ,  NISHIDA A (Hokkaido Coll. Pharmacy, Otaru, JPN) ,  KAWAHARA N (Hokkaido Coll. Pharmacy, Otaru, JPN)
Material： Tetrahedron  (Tetrahedron Symposia-in-Print)
Volume： 58  Issue： 49  Page： 9871-9877  Publication year： Dec. 02, 2002 
JST Material Number： E0234A  ISSN： 0040-4020  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： asymmetric synthesis ,...
Semi thesaurus term： Aldol condensation ,...

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JST classification (2)： Alkaloids  (CF10030D) ,  Eight or more-membered heterocyclic compounds  (CF07120T)

Substance index (20)： TAN-1251A ,  TAN-1251B ,  (5S)-4-Methyldispiro[1,4-diazabicyclo[3.2.1]octane-7,1′-cyclohexane-4′,2′′-[1,3]dioxolane]-3-one ,  (2S)-4β-(tert-Butyldiphenylsiloxy)-1-(tert-butoxycarbonyl)proline methyl ester ,  (4R)-1-(tert-Butoxycarbonyl)-2-(3-butenyl)-4-(tert-butyldiphenylsiloxy)-L-proline methyl ester ,  (2S)-2-(3-Butenyl)-2α-(hydroxymethyl)-4β-(tert-butyldiphenylsiloxy)pyrrolidine-1-carboxylic acid tert-butyl ester ,  (2S)-2-(3-Butenyl)-2α-formyl-4β-(tert-butyldiphenylsiloxy)pyrrolidine-1-carboxylic acid tert-butyl ester ,  (2S)-2-(3-Oxobutyl)-2α-formyl-4β-(tert-butyldiphenylsiloxy)pyrrolidine-1-carboxylic acid tert-butyl ester ,  (3R,5S)-3-(tert-Butyldiphenylsiloxy)-6-hydroxy-8-oxo-1-azaspiro[4.5]decane-1-carboxylic acid tert-butyl ester ,  (3R,5S)-3-(tert-Butyldiphenylsiloxy)-6-(mesyloxy)-8-oxo-1-azaspiro[4.5]decane-1-carboxylic acid tert-butyl ester ,  (3R,5S)-3-(tert-Butyldiphenylsiloxy)-8-oxo-1-azaspiro[4.5]deca-6-ene-1-carboxylic acid tert-butyl ester ,  (3R)-3-(tert-Butyldiphenylsiloxy)-8-oxo-1-azaspiro[4.5]decane-1-carboxylic acid tert-butyl ester ,  (4R)-4-(tert-Butyldiphenylsiloxy)dispiro[pyrrolidine-2,1′-cyclohexane-4′,2′′-[1,3]dioxolane]-1-carboxylic acid tert-butyl ester ,  (4R)-4-Hydroxydispiro[pyrrolidine-2,1′-cyclohexane-4′,2′′-[1,3]dioxolane]-1-carboxylic acid tert-butyl ester ,  (4S)-4-Azidodispiro[pyrrolidine-2,1′-cyclohexane-4′,2′′-[1,3]dioxolane]-1-carboxylic acid tert-butyl ester ,  (4S)-4-Azidodispiro[pyrrolidine-2,1′-cyclohexane-4′,2′′-[1,3]dioxolane] ,  (4S)-4-Azidodispiro[pyrrolidine-2,1′-cyclohexane-4′,2′′-[1,3]dioxolane]-1-acetic acid ethyl ester ,  (4S)-4-Aminodispiro[pyrrolidine-2,1′-cyclohexane-4′,2′′-[1,3]dioxolane]-1-acetic acid ethyl ester ,  (4S)-4-Aminodispiro[pyrrolidine-2,1′-cyclohexane-4′,2′′-[1,3]dioxolane]-1-acetic acid ,  (7S)-4,7-Methano-4,5,6,7-tetrahydrodispiro[1H-1,4-diazepine-5,1′-cyclohexane-4′,2′′-[1,3]dioxolane]-2(3H)-one

Terms in the title (2)： キラル ,  4-ヒドロキシ-L-プロリン