Art

J-GLOBAL ID：200902134484211491   Reference number：96A0899180

Structure-Activity Relationships Study of Two Series of Leukotriene B₄ Antagonists: Novel Indolyl and Naphthyl Compounds Substituted with a 2-[Methyl(2-phenethyl)amino]-2-oxoethyl Side Chain.

2種類のロイコトリエンB₄きっ抗薬シリーズの構造-活性相関研究 2-[メチル(2-フェネチル)アミノ]-2-オキソエチル側鎖で置換した新規インドリルおよびナフチル化合物

Author (9)： CHAN W K (Rh<span style=text-decoration:overline>o^</span>ne-Poulenc Rorer Central Res., Pennsylvania) ,  HUANG F-C (Rh<span style=text-decoration:overline>o^</span>ne-Poulenc Rorer Central Res., Pennsylvania) ,  MORRISSETTE M M (Rh<span style=text-decoration:overline>o^</span>ne-Poulenc Rorer Central Res., Pennsylvania) ,  WARUS J D (Rh<span style=text-decoration:overline>o^</span>ne-Poulenc Rorer Central Res., Pennsylvania) ,  MORIARTY K J (Rh<span style=text-decoration:overline>o^</span>ne-Poulenc Rorer Central Res., Pennsylvania) ,  GALEMMO R A (Rh<span style=text-decoration:overline>o^</span>ne-Poulenc Rorer Central Res., Pennsylvania) ,  DANKULICH W D (Rh<span style=text-decoration:overline>o^</span>ne-Poulenc Rorer Central Res., Pennsylvania) ,  POLI G (Rh<span style=text-decoration:overline>o^</span>ne-Poulenc Rorer Central Res., Pennsylvania) ,  SUTHERLAND C A (Rh<span style=text-decoration:overline>o^</span>ne-Poulenc Rorer Central Res., Pennsylvania)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 39  Issue： 19  Page： 3756-3768  Publication year： Sep. 13, 1996 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： ロイコトリエンB4受容体 ,...

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JST classification (2)： Basic research of histaminergic drugs and antihistaminergic drugs  (GW06010V) ,  Condensed derivatives of pyrroles  (CF07077C)

Substance index (30)： Leukotriene B4 ,  RG-14893 ,  4-(Benzyloxy)-N-methyl-N-phenethylbenzeneacetamide ,  1-[2-Oxo-2-(methylphenethylamino)ethyl]-5-(benzyloxy)-1H-indole-3-propenoic acid ,  1-[2-Oxo-2-(methylphenethylamino)ethyl]-6-(benzyloxy)-1H-indole-3-propenoic acid ,  1-[2-Oxo-2-(methylphenethylamino)ethyl]-7-(benzyloxy)-1H-indole-3-propenoic acid ,  1-[2-Oxo-2-(methylphenethylamino)ethyl]-4-(benzyloxy)-1H-indole-3-propenoic acid ,  1-[2-Oxo-2-(methylphenethylamino)ethyl]-α-methyl-5-(benzyloxy)-1H-indole-3-propenoic acid ,  1-[2-Oxo-2-(methylphenethylamino)ethyl]-α-ethyl-5-(benzyloxy)-1H-indole-3-propenoic acid ,  1-[2-Oxo-2-(methylphenethylamino)ethyl]-5-(benzyloxy)-1H-indole-3-propanoic acid ,  1-[2-Oxo-2-(methylphenethylamino)ethyl]-5-(benzyloxy)-1H-indole-3-acetic acid ,  1-[2-Oxo-2-(methylphenethylamino)ethyl]-5-(benzyloxy)-1H-indole-3-carboxylic acid ,  1-[2-Oxo-2-(methylphenethylamino)ethyl]-2-methyl-5-(benzyloxy)-1H-indole-3-carboxylic acid ,  1-[2-Oxo-2-(methylphenethylamino)ethyl]-5-(benzyloxy)-1H-indole-3-carbaldehyde ,  1-[2-Oxo-2-(methylphenethylamino)ethyl]-5-(benzyloxy)-1H-indole-3-propenoic acid ethyl ester ,  5-[1-[2-Oxo-2-(methylphenethylamino)ethyl]-5-(benzyloxy)-1H-indol-3-yl]-2,4-pentadienoic acid ,  4-[2-Oxo-2-(methylphenethylamino)ethyl]-7-(benzyloxy)naphthalene-2-carboxylic acid ,  4-[2-Oxo-2-(methylphenethylamino)ethyl]-1-(benzyloxy)naphthalene-2-carboxylic acid ,  4-[2-Oxo-2-(methylphenethylamino)ethyl]-8-(benzyloxy)naphthalene-2-propenoic acid ,  4-[2-Oxo-2-(methylphenethylamino)ethyl]-8-(benzyloxy)naphthalene-2-propanoic acid ,  4-[2-Oxo-2-(methylphenethylamino)ethyl]-8-(benzyloxy)naphthalene-2-pentanoic acid ,  4-[2-Oxo-2-(methylphenethylamino)ethyl]-α-ethyl-8-(benzyloxy)naphthalene-2-propenoic acid ,  4-[2-Oxo-2-(methylphenethylamino)ethyl]-8-phenoxynaphthalene-2-carboxylic acid ,  4-[2-Oxo-2-(methylphenethylamino)ethyl]-8-phenylnaphthalene-2-carboxylic acid ,  4-[2-Oxo-2-(methylphenethylamino)ethyl]-8-methoxynaphthalene-2-carboxylic acid ,  4-[2-Oxo-2-(methylphenethylamino)ethyl]-8-(pentyloxy)naphthalene-2-carboxylic acid ,  4-[2-Oxo-2-(methylphenethylamino)ethyl]-8-phenylnaphthalene-2-propenoic acid ,  4-[2-Oxo-2-(methylphenethylamino)ethyl]-8-phenylnaphthalene-2-propanoic acid ,  4-[2-Oxo-2-(methylphenethylamino)ethyl]-8-phenoxynaphthalene-2-propenoic acid ,  4-[2-Oxo-2-(methylphenethylamino)ethyl]-8-phenoxynaphthalene-2-propanoic acid

Terms in the title (7)： ロイコトリエンB4 ,  きっ抗薬 ,  構造-活性相関 ,  研究 ,  側鎖 ,  置換 ,  ドリル