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J-GLOBAL ID：200902135649769561   Reference number：02A0948722

Potentiation of Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells by a Coptidis Rhizoma Extract and Protoberberine Alkaloids.

黄連(Coptis Rhizome)根茎抽出物およびプロトベルベリンアルカロイドによるPC12細胞における神経成長因子誘導性神経突起伸長の促進

Author (6)： SHIGETA K (Hiroshima Prefectural Univ., Shobara, JPN) ,  OOTAKI K (Hiroshima Prefectural Univ., Shobara, JPN) ,  TATEMOTO H (Hiroshima Prefectural Univ., Shobara, JPN) ,  NAKANISHI T (Setsunan Univ., Hirakata, JPN) ,  INADA A (Setsunan Univ., Hirakata, JPN) ,  MUTO N (Hiroshima Prefectural Univ., Shobara, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 66  Issue： 11  Page： 2491-2494  Publication year： Nov. 23, 2002 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： PC12 cell ,...
Semi thesaurus term： NGF ,...

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JST classification (2)： Cell physiology in general  (EF02010S) ,  Plant biochemistry  (EH01050J)

Substance index (3)： Palmatine ,  Coptisine ,  Physostigmine

Reference (13)：

• 1) Eide, F. F., Lowenstein, D. H., and Reicharde, L. F., Neurotrophins and their receptors—current concepts and implications for neurological diseases. Exp. Neurol., 121, 200-214 (1993).
• 2) Fukuyama, Y., Otoshi, Y., Miyoshi, K., Nakamura, K., Kodama, M., Nagasawa, M., Hasegawa, T., Okazaki, H., and Sugawara, M., Neurotrophic sesquiterpene-neolignans from Magnolia obovata: structure and neurotrophic activity. Tetrahedron, 48, 377-392 (1992).
• 3) Qi, J., Ojika, M., and Sakagami, Y., Differentiation in a rat PC12 cell line induced by ostruthin and (−)-bornyl ferulate, constituents of a Chinese herbal medicine. Biosci. Biotechnol. Biochem., 63, 1501-1502 (1999).
• 4) Li, P., Matsunaga, K., Yamakuni, T., and Ohizumi, Y., Potentiation of nerve growth factor action by picrosides I and II, natural iridoids, in PC12D cells. Eur. J. Pharmacol., 406, 203-208 (2000).
• 5) Li, P., Matsunaga, K., and Ohizumi, Y., Enhancement of the nerve growth factor-mediated neurite outgrowth from PC12D cells by Chinese and Paraguayan medicinal plants. Biol. Pharm. Bull., 22, 752-755 (1999).

Terms in the title (8)： 黄連 ,  根茎 ,  抽出物 ,  プロトベルベリンアルカロイド ,  PC12細胞 ,  神経成長因子 ,  神経突起伸長 ,  促進