Art

J-GLOBAL ID：200902135750686847   Reference number：02A0033906

Optimization of 4-Phenylamino-3-quinolinecarbonitriles as Potent Inhibitors of Src Kinase Activity.

Srcキナーゼ活性の強力な阻害薬としての4-フェニルアミノ-3-キノリンカルボニトリル類の最適化

Author (9)： BOSCHELLI D H (Wyeth-Ayerst Res., New York) ,  DUTIA M (Wyeth-Ayerst Res., New York) ,  MILLER K (Wyeth-Ayerst Res., New York) ,  YACZKO D (Wyeth-Ayerst Res., New York) ,  TISCHLER M (Wyeth-Ayerst Res., New York) ,  DISCAFANI C (Wyeth-Ayerst Res., New York) ,  GIBBONS J (Wyeth-Ayerst Res., New York) ,  LUCAS J (Wyeth-Ayerst Res., New York) ,  BOSCHELLI F (Wyeth-Ayerst Res., New York)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 44  Issue： 23  Page： 3965-3977  Publication year： Nov. 08, 2001 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： nitrogen heterocyclic compound ,...

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JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Quinolines,isoquinolines  (CF07096H)

Substance index (33)： 4-(2,4-Dichloroanilino)-6,7-dimethoxy-3-quinolinecarbonitrile ,  4-(2-Chloro-5-methoxyanilino)-6,7-dimethoxyquinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6,7-dimethoxyquinoline-3-carbonitrile ,  4-(2-Bromo-4-chloro-5-methoxyanilino)-6,7-dimethoxyquinoline-3-carbonitrile ,  4-(2-Methyl-4-chloro-5-methoxyanilino)-6,7-dimethoxyquinoline-3-carbonitrile ,  4-(2-Iodo-4-chloroanilino)-6,7-dimethoxyquinoline-3-carbonitrile ,  4-(2-Chloro-4-methyl-5-methoxyanilino)-6,7-dimethoxyquinoline-3-carbonitrile ,  4-(2,4-Dimethyl-5-methoxyanilino)-6,7-dimethoxyquinoline-3-carbonitrile ,  4-(2,4-Dichloroanilino)-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile ,  4-(2-Chloro-5-methoxyanilino)-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile ,  4-(2-Bromo-4-chloro-5-methoxyanilino)-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile ,  4-(2-Methyl-4-chloro-5-methoxyanilino)-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile ,  4-(2,4-Dimethyl-5-methoxyanilino)-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile ,  4-(2-Chloro-4-methyl-5-methoxyanilino)-6-methoxy-7-(3-morpholinopropoxy)quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-7-methoxy-6-(3-morpholinopropoxy)quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-(2-morpholinoethoxy)quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-(4-morpholinobutoxy)quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-(5-morpholinopentyloxy)quinoline-3-carbonitrile ,  SKI-606 ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-ethylpiperazino)propoxy]quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(3α,4α,5α-trimethylpiperazino)propoxy]quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-propylpiperazino)propoxy]quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-(3-piperazinopropoxy)quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-[4-(2-hydroxyethyl)piperazino]propoxy]quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylhexahydro-1H-1,4-diazepine-1-yl)propoxy]quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-(3-piperidinopropoxy)quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-hydroxypiperidino)propoxy]quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(2H-1,2,3-triazole-2-yl)propoxy]quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(1H-1,2,3-triazole-1-yl)propoxy]quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(1H-imidazole-1-yl)propoxy]quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(2-morpholinoethylamino)propoxy]quinoline-3-carbonitrile ,  4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-[N-methyl-2-(dimethylamino)ethylamino]propoxy]quinoline-3-carbonitrile

Terms in the title (5)： Srcキナーゼ ,  活性 ,  阻害薬 ,  3-キノリンカルボニトリル ,  最適化