Mechanism for Phosphorylation-induced Activation of the Phagocyte NADPH Oxidase Protein p47<sup>phox</sup>. Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47<sup>phox</sup>, thereby activating the oxidase.

AGO T; NUNOI H; ITO T; SUMIMOTO H

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J-GLOBAL ID：200902136918727680 Reference number：00A0120078

Mechanism for Phosphorylation-induced Activation of the Phagocyte NADPH Oxidase Protein p47^phox. Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47^phox, thereby activating the oxidase.

食細胞NADPHオキシダーゼ蛋白質p47^phoxの燐酸化で誘起される活性化の機構 p47^phox内のセリン303,304及び328のアスパラギン酸による三重置換はSH3ドメインで仲介される分子内相互作用を破壊し,それによりオキシダーゼを活性化する

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Volume： 274 Issue： 47 Page： 33644-33653 Publication year： Nov. 19, 1999
JST Material Number： E0038A ISSN： 0021-9258 CODEN： JBCHA3 Document type： Article
Article type：原著論文 Country of issue： United States (USA) Language： ENGLISH (EN)

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Mechanism for Phosphorylation-induced Activation of the Phagocyte NADPH Oxidase Protein p47phox. Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47phox, thereby activating the oxidase.

Mechanism for Phosphorylation-induced Activation of the Phagocyte NADPH Oxidase Protein p47^phox. Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47^phox, thereby activating the oxidase.