Art

J-GLOBAL ID：200902137638251156   Reference number：95A0686409

Synthesis, Antimicrobial Activity and In vivo Fluorine NMR of a Hexafluorinated Derivative of Tilmicosin.

ヘキサふっ素化チルミコシン誘導体の合成 抗菌活性及びin vivoふっ素NMR

Author (5)： CREEMER L C (Lilly Res. Lab., IN, USA) ,  KIRST H A (Lilly Res. Lab., IN, USA) ,  SHRYOCK T R (Lilly Res. Lab., IN, USA) ,  CAMPBELL J B (Lilly Res. Lab., IN, USA) ,  WEBB A G (Univ. Illinois, IL, USA)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 48  Issue： 7  Page： 671-675  Publication year： Jul. 1995 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： macrolide antibiotics ,...
Semi thesaurus term： Staphylococcus epidermidis ,...

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JST classification (2)： Synthesis of antibiotics  (GX04000Z) ,  Basic research of antibiotics acting on pathogenic organisms  (GX05020C)

Reference (7)：

• 1) BRYSKIER, A. & J.-F. CHANTOT: Pharmacokinetic behavior of macrolide antibiotics in animals. In Macrolides: Chemistry, Pharmacology, and Clinical Uses. Eds. A. J. BRYSKIER, J.-P. BUTZLER, H. C. NEU, P. M. TULKENS, pp. 341-375, Arnette Blackwell, Paris, 1993
• 2) KIRST, H. A.: Chapter 5. Semi-synthetic derivatives of 16-membered macrolide antibiotics. In Progress in Medicinal Chemistry Vol. 31. Ed. G. P. ELLIS, et al., pp. 265-295, Elsevier Scienee B.V., Amsterdam, 1994
• 3) PLAZEK, E.: Ueber Eine Synthese des 3,5-Dinitropyridins. Rec. Trav. Chim. Pays-Bas 72: 569-575, 1953
• 5) SCHREIBER, K. & A. GÜNTER: Eine neue Eifache Synthese der Fusarinäsure. Chem. Ber. 93: 1848-1851, 1960
• 6) SNOW, R. J. & L. J. STREET: Synthesis of 3,5-disubstituted 1-azabicyclic systems: Intermediates for novel muscarinic ligands. Tetrahedron Lett. 30: 5795-5798, 1989

Terms in the title (6)： ふっ素化 ,  チルミコシン ,  誘導体 ,  抗菌活性 ,  ふっ素 ,  NMR