Art

J-GLOBAL ID：200902137905877035   Reference number：03A0045413

Practical Total Synthesis of Ciguatoxin CTX3C by Improved Protective Group Strategy.

改良された保護基の戦略によるシグアトキシンCTX3Cの実用的な全合成

Author (4)： INOUE M (Tohoku Univ., Sendai, JPN) ,  UEHARA H (Tohoku Univ., Sendai, JPN) ,  MARUYAMA M (Tohoku Univ., Sendai, JPN) ,  HIRAMA M (Tohoku Univ., Sendai, JPN)
Material： Organic Letters  (Org Lett)
Volume： 4  Issue： 25  Page： 4551-4554  Publication year： Dec. 12, 2002 
JST Material Number： W1171A  ISSN： 1523-7060  CODEN： ORLEF7  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *cyclic ether ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=03A0045413&from=J-GLOBAL&jstjournalNo=W1171A") }}

JST classification (2)： Eight or more-membered heterocyclic compounds  (CF07120T) ,  Toxicity of animal derived substances  (GZ03020U)

Substance index (12)： Ciguatoxin 3C ,  (2Z,5S,6S,7R,8R,9R,11S,12R,13Z,15S,16R,18Z,20S,21R)-7-(2-Naphthylmethoxy)-1,6:5,9:8,12:11,16:15,21-pentaepoxytricosane-2,13,18-triene-20,23-diol ,  (3R,4S,5R,7S,8R,10R,12S,13R,15S,16R,17S,18S,19S,20R,21S,22S,23R)-3,18-Bis(2-naphthylmethoxy)-4,10,17,21,22-pentamethyl-5-(triisopropylsiloxy)-4,8:7,13:12,16:15,20:19,23:23,26-hexaepoxyhexacosanal ,  (3R,4S,5R,7S,8R,10R,12S,13R,15S,16R,17S,18S,19S,20R,21S,22S,23R)-3,18-Bis(2-naphthylmethoxy)-4,10,17,21,22-pentamethyl-5-(triisopropylsiloxy)-4,8:7,13:12,16:15,20:19,23:23,26-hexaepoxyhexacosanal diphenyldithioacetal ,  (2Z,5S,6S,7R,8R,9R,11S,12R,13Z,15S,16R,18Z,20S,21R,27R,28S,29R,31S,32R,34R,36S,37R,39S,40R,41S,42S,43S,44R,45S,46S,47R)-7,27,42-Tris(2-naphthylmethoxy)-28,34,41,45,46-pentamethyl-29-(triisopropylsiloxy)-1,6:5,9:8,12:11,16:15,21:20,25:28,32:31,37:36,40:39,44:43,47:47,50-dodecaepoxy-24-oxapentacontane-2,13,18-triene ,  (2Z,5S,6S,7R,8R,9R,11S,12R,13Z,15S,16R,18Z,20S,24R,25S,26R,28S,29R,31R,33S,34R,36S,37R,38S,39S,40S,41R,42S,43S,44R,54R)-7,24,39-Tris(2-naphthylmethoxy)-22-(phenylthio)-25,31,38,42,43-pentamethyl-26-(triisopropylsiloxy)-54-(2-hydroxyethyl)-1,6:5,9:8,12:11,16:25,29:28,34:33,37:36,41:40,44:44,47-decaepoxy-15,20-(epoxymethano)-21-oxaheptatetracontane-2,13,18-triene ,  (2Z,5S,6S,7R,8R,9R,11S,12R,13Z,15S,16R,18Z,20S,24R,25S,26R,28S,29R,31R,33S,34R,36S,37R,38S,39S,40S,41R,42S,43S,44R,54R)-7,24,39-Tris(2-naphthylmethoxy)-22-(phenylthio)-25,31,38,42,43-pentamethyl-26-(triisopropylsiloxy)-54-[2-(2-ethoxyethoxy)ethyl]-1,6:5,9:8,12:11,16:25,29:28,34:33,37:36,41:40,44:44,47-decaepoxy-15,20-(epoxymethano)-21-oxaheptatetracontane-2,13,18-triene ,  (2Z,5S,6S,7R,8R,9R,11S,12R,13Z,15S,16R,18Z,20S,24R,25S,26R,28S,29R,31R,33S,34R,36S,37R,38S,39S,40S,41R,42S,43S,44R,54R)-7,24,39-Tris(2-naphthylmethoxy)-22-(phenylthio)-25,31,38,42,43-pentamethyl-26-[[(E)-3-oxo-3-methoxy-1-propenyl]oxy]-54-[2-(2-ethoxyethoxy)ethyl]-1,6:5,9:8,12:11,16:25,29:28,34:33,37:36,41:40,44:44,47-decaepoxy-15,20-(epoxymethano)-21-oxaheptatetracontane-2,13,18-triene ,  (2Z,5S,6S,7R,8R,9R,11S,12R,13Z,15S,16R,18Z,20S,22R,24R,25S,26R,28S,29R,31R,33S,34R,36S,37R,38S,39S,40S,41R,42S,43S,44R,55S,56R)-7,24,39-Tris(2-naphthylmethoxy)-25,31,38,42,43-pentamethyl-55-(2-oxo-2-methoxyethyl)-56-[2-(2-ethoxyethoxy)ethyl]-1,6:5,9:8,12:11,16:25,29:28,34:33,37:36,41:40,44:44,47-decaepoxy-15,20:26,22-bis(epoxymethano)-21-oxaheptatetracontane-2,13,18-triene ,  (3R,4S,5Z,8R,9S,10Z,12R,13S,15R,16R,17R,18S,19S,21Z)-4-[[(4S,5R,7R,8S,9R,11S,12R,14R,16S,17R,19S,20R,21S,22S,23S,24R,25S,26S,27R)-7,22-Bis(2-naphthylmethoxy)-8,14,21,25,26-pentamethyl-4,9:8,12:11,17:16,20:19,24:23,27:27,30-heptaepoxy-1-triacontene-5-yl]oxy]-17-(2-naphthylmethoxy)-3,9:8,13:12,16:15,19:18,23-pentaepoxytricosa-5,10,21-triene-1-ol ,  (2Z,5S,6S,7R,8R,9R,11S,12R,13Z,15S,16R,18Z,20S,22R,24R,25S,26R,28S,29R,31R,33S,34R,36S,37R,38S,39S,40S,41R,42S,43S,44R,55S,56R)-7,24,39-Tris(2-naphthylmethoxy)-25,31,38,42,43-pentamethyl-55,56-diallyl-1,6:5,9:8,12:11,16:25,29:28,34:33,37:36,41:40,44:44,47-decaepoxy-15,20:26,22-bis(epoxymethano)-21-oxaheptatetracontane-2,13,18-triene ,  (2Z,5S,6R,7R,8S,9R,11S,12R,13Z,15S,16R,18Z,20S,21R,23Z,26S,27R,29R,30S,31R,33S,34R,36R,38S,39R,41S,42R,43S,44S,45S,46R,47S,48S,49R)-7,29,44-Tris(2-naphthylmethoxy)-30,36,43,47,48-pentamethyl-1,6:5,9:8,12:11,16:15,21:20,27:26,31:30,34:33,39:38,42:41,46:45,49:49,52-tridecaepoxydopentacontane-2,13,18,23-tetrene

Terms in the title (5)： 保護基 ,  戦略 ,  シグアトキシン ,  CTX3C ,  全合成