GEX1 Compounds, Novel Antitumor Antibiotics Related to Herboxidiene, Produced by Streptomyces sp. I. Taxonomy, Production, Isolation, Physicochemical Properties and Biological Activities.

SAKAI Y; YOSHIDA T; OCHIAI K; UOSAKI Y; SAITOH Y; TANAKA F; AKIYAMA T; AKINAGA S; MIZUKAMI T

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J-GLOBAL ID：200902137907699584 Reference number：02A0869636

GEX1 Compounds, Novel Antitumor Antibiotics Related to Herboxidiene, Produced by Streptomyces sp. I. Taxonomy, Production, Isolation, Physicochemical Properties and Biological Activities.

Streptomycessp.が産生するヘルボキシジエンに関連する新規抗腫よう抗生物質であるGEX1化合物 I 分類,産生,単離,物理化学的性質及び生物活性

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Material：
Volume： 55 Issue： 10 Page： 855-862 Publication year： Oct. 25, 2002
JST Material Number： G0489A ISSN： 0021-8820 Document type： Article
Article type：原著論文 Country of issue： Japan (JPN) Language： ENGLISH (EN)

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Basic research of antitumor(=antineoplastic)antibiotics

Reference (9)：

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2) SHIRLING, E. B. & D. GOTTLIEB: Methods for characterization of Streptomyces species. Int. J. Syst. Bacteriol. 16: 313-340, 1966
3) CARMICHAEL, J.; W. G. DEGRAFF, A. F. GAZDAR, J. D. MINNA & J. B. MITCHELL: Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing. Cancer Res. 47: 936-942, 1987
4) AKINAGA, S.; K. GOMI, M. MORIMOTO, T. TAMAOKI & M. OKABE: Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models. Cancer Res. 51: 4888-4892, 1991
5) ISAAC, B.; S. AYER & R. STONARD: Microorganisms, a remarkable source of diverse chemical structures for herbicide discovery. Environ. Sci. Res. 44: 157-187, 1992

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