Art

J-GLOBAL ID：200902138987976318   Reference number：93A0668340

Delaminomycins, novel extracellular matrix receptor antagonist.

デラミノマイシン類,新規の細胞外基質受容体きっ抗剤 IV デラミノマイシン類と誘導体の構造活性相関

Author (9)： UENO M (Microbial Chemistry Research Foundation, Shizuoka, JPN) ,  AMEMIYA M (Microbial Chemistry Research Foundation, Shizuoka, JPN) ,  YAMAZAKI K (Microbial Chemistry Research Foundation, Shizuoka, JPN) ,  IIJIMA M (Microbial Chemistry Research Foundation, Shizuoka, JPN) ,  OSONO M (Microbial Chemistry Research Foundation, Shizuoka, JPN) ,  SOMENO T (Microbial Chemistry Research Foundation, Shizuoka, JPN) ,  IINUMA H (Microbial Chemistry Research Foundation, Tokyo, JPN) ,  HAMADA M (Microbial Chemistry Research Foundation, Tokyo, JPN) ,  TAKEUCHI T (Microbial Chemistry Research Foundation, Shizuoka, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 46  Issue： 7  Page： 1156-1162  Publication year： Jul. 1993 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： antineoplastic antibiotics ,...
Semi thesaurus term： デラミノマイシン

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JST classification (2)： Antibiotics in general  (GX01000E) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (7)： Delaminomycin A ,  Delaminomycin B ,  2-[(1E,3E)-5-Methyl-6-hydroxy-1,3-octadienyl]-1,2,4a,4b,5,6,7,8,8a,10a-decahydro-4a,5,7-trimethyl-5′-hydroxyspiro[phenanthrene-3(4H),3′-pyrrolidine]-2′,4,4′-trione ,  2-[(1E,3E)-5-Methyl-6-hydroxy-1,3-octadienyl]-1,2,4a,4b,5,6,7,8,8a,10a-decahydro-4a,5,7-trimethyl-5′-methoxyspiro[phenanthrene-3(4H),3′-pyrrolidine]-2′,4,4′-trione ,  2-[(1E,3E)-5-Methyl-6-hydroxy-1,3-octadienyl]-1,2,4a,4b,5,6,7,8,8a,10a-decahydro-4a,5,7-trimethylspiro[phenanthrene-3(4H),3′-pyrrolidine]-2′,4,4′-trione ,  1,6,8-Trimethyl-1,2,4a,5,6,7,8,8a-octahydro-2-[(3E,5E)-2,8-dihydroxy-7-methyl-3,5-decadienyl]-β-oxo-1-naphthalenepropanamide ,  2-[(1E,3E)-5-Methyl-6-hydroxy-1,3-octadienyl]-3-(dihydroxyacetyl)-4-hydroxy-4a,5,7-trimethyl-1,2,3,4,4a,4b,5,6,7,8,8a,10a-dodecahydrophenanthrene-3-carboxamide

Reference (5)：

• 1) UENO, M.; M. AMEMIYA, M. OSONO, N. KINOSHITA, T. IKEDA, H. IINUMA, M. HAMADA, M. ISHIZUKA & T. TAKEUCHI: Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. I. Taxonomy, fermentation, isolation and biological activity. J. Antibiotics 46:719-727,1993
• 2) UENO, M.; T. SOMENO, R. SAWA, H. IINUMA, H. NAGANAWA, M. ISHIZUKA & T. TAKEUCHI: Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. II. Physico-chemical properties and structure elucidation of delaminomycin A. J. Antibiotics 46: 979-984, 1993
• 3) UENO, M.; T. SOMENO, R. SAWA, H. IINUMA, H. NAGANAWA, M. ISHIZUKA & T. TAKEUCHI: Delaminomycins, novel extracellular matrix receptor antagonist. III. Physico-chemical properties and structure elucidation of delaminomycins B and C. J. Antibiotics 46: 1020-1023, 1993
• 4) GRAF, J.; Y. IWAMOTO, M. SASAKI, G. R. MARTIN, H. K. KLEINMAN, F. A. ROBEY & Y. YAMADA: Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding. Cell 48: 989-996, 1987
• 5) GRAF, J.; R. C. OGLE, F. A. ROBEY, M. SASAKI, G. R. MARTIN, Y. YAMADA & H. K. KLEINMAN: A Pentapeptide from the laminin B1 chain mediates cell adhesion and binds the 67,000 laminin receptor. Biochem. 26: 6896-6900, 1987

Terms in the title (5)： 細胞外基質 ,  受容体 ,  きっ抗剤 ,  誘導体 ,  構造活性相関