Art

J-GLOBAL ID：200902139721117405   Reference number：97A0288304

Synthesis and Aromatase-Inhibitory Activity of Imidazolyl-1,3,5-triazine Derivatives.

イミダゾリル-1,3,5-トリアジン誘導体の合成とアロマターゼ-阻害作用

Author (6)： MATSUNO T (Zenyaku Kogyo Co., Ltd., Tokyo, JPN) ,  KATO M (Zenyaku Kogyo Co., Ltd., Tokyo, JPN) ,  TSUCHIDA Y (Zenyaku Kogyo Co., Ltd., Tokyo, JPN) ,  TAKAHASHI M (Zenyaku Kogyo Co., Ltd., Tokyo, JPN) ,  YAGUCHI S (Zenyaku Kogyo Co., Ltd., Tokyo, JPN) ,  TERADA S (Zenyaku Kogyo Co., Ltd., Tokyo, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 45  Issue： 2  Page： 291-296  Publication year： Feb. 1997 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Aromatase ,...
Semi thesaurus term： triazines ,...

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JST classification (2)： Triazines  (CF07107M) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (34)： Aminoglutethimide ,  Altretamine ,  Cyanuric chloride ,  2-Chloro-4,6-bis(dimethylamino)-1,3,5-triazine ,  2-Chloro-4,6-dipiperidino-1,3,5-triazine ,  2,4-Bisthiomorpholino-6-chloro-1,3,5-triazine ,  2,4-Dichloro-6-(dimethylamino)-1,3,5-triazine ,  2,4-Dichloro-6-morpholino-1,3,5-triazine ,  2,4-Dichloro-6-(N-methylanilino)-1,3,5-triazine ,  N,N,N′-Trimethyl-6-chloro-1,3,5-triazine-2,4-diamine ,  N,N,N′,N′-Tetramethyl-6-(1H-imidazol-1-yl)-1,3,5-triazine-2,4-diamine ,  N,N,N′-Trimethyl-6-(1H-imidazol-1-yl)-1,3,5-triazine-2,4-diamine ,  N,N,N′,N′-Tetramethyl-6-(2-isopropyl-1H-imidazol-1-yl)-1,3,5-triazine-2,4-diamine ,  N,N,N′,N′-Tetramethyl-6-(4,5-dimethyl-1H-imidazol-1-yl)-1,3,5-triazine-2,4-diamine ,  N,N-Dimethyl-4,6-bis(1H-imidazol-1-yl)-1,3,5-triazin-2-amine ,  N,N-Dimethyl-4-(1H-imidazol-1-yl)-6-(2-isopropyl-1H-imidazol-1-yl)-1,3,5-triazin-2-amine ,  N,N-Dimethyl-4-(1H-imidazol-1-yl)-6-(4,5-dimethyl-1H-imidazol-1-yl)-1,3,5-triazin-2-amine ,  N,N-Dimethyl-4-pyrrolizino-6-(1H-imidazol-1-yl)-1,3,5-triazin-2-amine ,  N,N-Dimethyl-4-piperidino-6-(1H-imidazol-1-yl)-1,3,5-triazin-2-amine ,  N,N-Dimethyl-4-morpholino-6-(1H-imidazol-1-yl)-1,3,5-triazin-2-amine ,  2,4-Dipyrrolizino-6-(1H-imidazol-1-yl)-1,3,5-triazine ,  2,4-Dipiperidino-6-(1H-imidazol-1-yl)-1,3,5-triazine ,  SEF-19 ,  2-Morpholino-4,6-bis(1H-imidazol-1-yl)-1,3,5-triazine ,  2,4,6-Tri(4-morpholinyl)-1,3,5-triazine ,  2,4-Dimorpholino-6-(1H-pyrazol-1-yl)-1,3,5-triazine ,  2,4-Dimorpholino-6-(1H-1,2,3-triazol-1-yl)-1,3,5-triazine ,  2-Morpholino-4-(2α,6α-dimethylmorpholino)-6-(1H-imidazol-1-yl)-1,3,5-triazine ,  2-Morpholino-4-(2-thiazolidinyl)-6-(1H-imidazol-1-yl)-1,3,5-triazine ,  2-Morpholino-4-(4-benzylpiperazino)-6-(1H-imidazol-1-yl)-1,3,5-triazine ,  2-Morpholino-4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-(1H-imidazol-1-yl)-1,3,5-triazine ,  1-[4-Morpholino-6-(1H-imidazol-1-yl)-1,3,5-triazin-2-yl]-4-phenylpiperidine-4-carbonitrile ,  N-Methyl-N-phenyl-4-morpholino-6-(1H-imidazol-1-yl)-1,3,5-triazin-2-amine ,  2,4-Bisthiomorpholino-6-(1H-imidazol-1-yl)-1,3,5-triazine

Reference (21)：

• BRODIE, A. Biochem.Pharmacol. 1985, 34, 3213-3219
• van WAUWE, J. P. J.Med.Chem. 1989, 32, 2231-2239
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• THOMPSON, E. A., Jr. J.Biol.Chem. 1974, 249, 5364-5372
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Terms in the title (4)： イミダゾリル ,  トリアジン誘導体 ,  アロマターゼ ,  阻害作用