Art

J-GLOBAL ID：200902140609488580   Reference number：01A0664792

Synthesis and Evaluation of a Difluoromethylene Analogue of Sphingomyelin as an Inhibitor of Sphingomyelinase.

スフィンゴミェリナーゼ阻害剤としてのスフィンゴミェリン ジフルオロメチレン類似体の合成と評価

Author (7)： YOKOMATSU T (Tokyo Univ. Pharmacy & Life Sci., Tokyo, JPN) ,  TAKECHI H (Tokyo Univ. Pharmacy & Life Sci., Tokyo, JPN) ,  AKIYAMA T (Tokyo Univ. Pharmacy & Life Sci., Tokyo, JPN) ,  SHIBUYA S (Tokyo Univ. Pharmacy & Life Sci., Tokyo, JPN) ,  KOMINATO T (Fukuoka Univ., Fukuoka, JPN) ,  SOEDA S (Fukuoka Univ., Fukuoka, JPN) ,  SHIMENO H (Fukuoka Univ., Fukuoka, JPN)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 11  Issue： 10  Page： 1277-1280  Publication year： May. 21, 2001 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *sphingomyelinase ,...

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JST classification (2)： Enzyme in general  (EB09010D) ,  Synthesis of drugs  (GV01030F)

Substance index (5)： Stearoylsphingomyelin ,  [[(2R,3R)-1,1-Difluoro-2-(octadecanoylamino)-3-hydroxy-4-nonadecenyl]phosphonic acid [2-(trimethylaminio)ethyl]]anion ,  [(3R,4R)-1,1-Difluoro-2,4-dihydroxy-3-(octadecanoylamino)-4-phenylbutyl]phosphonic acid ,  [[(3R,4R)-1,1-Difluoro-2,4-dihydroxy-3-(octadecanoylamino)-4-phenylbutyl]phosphonic acid [2-(trimethylaminio)ethyl]]anion ,  (4S)-2,2-Dimethyl-4α-[(R)-α-hydroxybenzyl]oxazolidine-3-carboxylic acid tert-butyl ester

Terms in the title (3)： 阻害剤 ,  類似体 ,  評価