Art

J-GLOBAL ID：200902140742508747   Reference number：99A0751392

Novel Multidrug Resistance Reversal Agents.

新しい多剤耐性逆転薬

Author (7)： BERGER D (Wyeth-Ayerst Res., New York) ,  CITARELLA R (Wyeth-Ayerst Res., New York) ,  DUTIA M (Wyeth-Ayerst Res., New York) ,  GREENBERGER L (Wyeth-Ayerst Res., New York) ,  HALLETT W (Wyeth-Ayerst Res., New York) ,  PAUL R (Wyeth-Ayerst Res., New York) ,  POWELL D (Wyeth-Ayerst Res., New York)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 42  Issue： 12  Page： 2145-2161  Publication year： Jun. 17, 1999 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： nitrogen heterocyclic compound ,...

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JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Quinolines,isoquinolines  (CF07096H)

Substance index (25)： 2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-5-[(6,7-dimethoxy-3,4-dihydroisoquinolin)-2(1H)-yl]pentanenitrile ,  2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-6-[(6,7-dimethoxy-3,4-dihydroisoquinoline)-2(1H)-yl]hexanenitrile ,  2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-4-[(6,7-dimethoxy-3,4-dihydroisoquinoline)-2(1H)-yl]butanenitrile ,  2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-5-[(6,7-dimethoxy-3,4-dihydroisoquinoline)-2(1H)-yl]pentanoic acid methyl ester ,  2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-13-[(6,7-dimethoxy-3,4-dihydroisoquinoline)-2(1H)-yl]tridecanenitrile ,  2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-7-[(3,4-dihydroisoquinoline)-2(1H)-yl]heptanenitrile ,  2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-7-[(6,7-dimethoxy-3,4-dihydroisoquinoline)-2(1H)-yl]heptanenitrile ,  2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-10-[(6,7-dimethoxy-3,4-dihydroisoquinoline)-2(1H)-yl]decanenitrile ,  2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-7-[(7,8-dihydro-1,3-dioxolo[4,5-g]isoquinoline)-6(5H)-yl]heptanenitrile ,  2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-7-[(6-methoxy-3,4-dihydroisoquinoline)-2(1H)-yl]heptanenitrile ,  2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-7-(5,6-dimethoxyisoindoline-2-yl)heptanenitrile ,  2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-7-(5,6-dichloroisoindoline-2-yl)heptanenitrile ,  2-(3,4-Dimethoxyphenyl)-2-(cyclohexylthio)-7-(5,6-dimethoxyisoindoline-2-yl)heptanenitrile ,  1-(3,4-Dimethoxyphenyl)-1-(cyclohexylthio)-6-[(6,7-dimethoxy-3,4-dihydroisoquinoline)-2(1H)-yl]hexane ,  1-(3,4-Dimethoxyphenyl)-1-(benzylthio)-6-[(6,7-dimethoxy-3,4-dihydroisoquinoline)-2(1H)-yl]hexane ,  1-(3,4-Dimethoxyphenyl)-1-(tert-butylthio)-6-[(6,7-dimethoxy-3,4-dihydroisoquinoline)-2(1H)-yl]hexane ,  1-(3,4-Dimethoxyphenyl)-1-(pentylthio)-6-[(6,7-dimethoxy-3,4-dihydroisoquinoline)-2(1H)-yl]hexane ,  6-(3,4-Dimethoxyphenyl)-6-(p-tolylthio)-1-[(6,7-dimethoxy-3,4-dihydroisoquinoline)-2(1H)-yl]octane ,  1-(3-Hydroxy-4-methoxyphenyl)-1-(p-tolylthio)-7-[(6,7-dimethoxy-3,4-dihydroisoquinoline)-2(1H)-yl]heptane ,  1-[3-(2-Chloroethoxy)-4-methoxyphenyl]-1-(p-tolylthio)-7-[(6,7-dimethoxy-3,4-dihydroisoquinoline)-2(1H)-yl]heptane ,  2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-7-[[6-methoxy-7-[2-(1H-imidazole-1-yl)ethoxy]-3,4-dihydroisoquinoline]-2(1H)-yl]heptanenitrile ,  2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-7-[5-methoxy-6-[2-(1H-imidazole-1-yl)ethoxy]isoindoline-2-yl]heptanenitrile ,  2-(3,4-Dimethoxyphenyl)-2-(cyclohexylthio)-7-[[6-methoxy-7-[2-(1H-imidazole-1-yl)ethoxy]-3,4-dihydroisoquinoline]-2(1H)-yl]heptanenitrile ,  2-(3,4-Dimethoxyphenyl)-2-(p-tolylthio)-7-[[6-methoxy-7-[2-(dimethylamino)ethoxy]-3,4-dihydroisoquinoline]-2(1H)-yl]heptanenitrile ,  1-[3-[2-(1H-Imidazole-1-yl)ethoxy]-4-methoxyphenyl]-1-(p-tolylthio)-7-[(6,7-dimethoxy-3,4-dihydroisoquinoline)-2(1H)-yl]heptane

Terms in the title (2)： 多剤耐性 ,  逆転