Art

J-GLOBAL ID：200902141595440771   Reference number：01A0738911

Free Radical-Mediated Tolbutamide Desensitization of K⁺_ATP Channels in Rat Pancreatic β-cells.

ラットすい臓β細胞におけるK⁺_ATPチャンネルの遊離ラジカル仲介トルブタミド脱感作

Author (9)： KORIYAMA N (Kagoshima Univ., Kagoshima, JPN) ,  KAKEI M (Akita Univ. School of Medicine, Akita, JPN) ,  NAKAZAKI M (Kagoshima Univ., Kagoshima, JPN) ,  YAEKURA K (Kagoshima Univ., Kagoshima, JPN) ,  HASHIGUCHI H (Kagoshima Univ., Kagoshima, JPN) ,  ASO K (Kagoshima Univ., Kagoshima, JPN) ,  YADA T (Jichi Medical School, Tochigi, JPN) ,  ITO S (Akita Univ. School of Medicine, Akita, JPN) ,  TEI C (Kagoshima Univ., Kagoshima, JPN)
Material： Endocrine Journal  (Endocr J)
Volume： 48  Issue： 3  Page： 337-344  Publication year： Jun. 2001 
JST Material Number： F0625A  ISSN： 0918-8959  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： pancreas beta cell

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JST classification (2)： Transport of cell membrane  (EF04020R) ,  Pancreas  (EJ06050Y)

Substance index (2)： adenosine triphosphate ,  Tolbutamide

Reference (31)：

• 1). Ashcroft FM, Rorsman P (1989) Electrophysiology of the pancreatic β-cell. Prog Biophys Molec Biol 54: 87-143.
• 2). Kakei M, Kelly RP, Ashcroft SJH, Ashcroft FM (1986) The ATP-sensitivity of K⁺ channels in rat pancreatic B-cells is modulated by ADP. FEBS Lett 208: 63-66.
• 3). Zünkler BJ, Lins S, Ohno-Shosaku T, Trube G, Panten U (1988) Cytosolic ADP enhances the sensitivity to tolbutamide of ATP-dependent K⁺ channels from pancreatic B-cells. FEBS Lett 239: 241-244.
• 4). Schwanstecher C, Dickel C, Panten U (1992) Cytosolic nucleotides enhance the tolbutamide sensitivity of the ATP-dependent K⁺ channel in mouse pancreatic B cells by their combined actions at inhibitory and stimulatory receptors. Mol Pharmacol 41: 480-486.
• 5). Findlay I (1993) Sulfonylurea drugs no longer inhibit ATP-sensitive K⁺ channels during metabolic stress in cardiac muscle. J Pharmacol Exp Ther 266: 456-467.

Terms in the title (7)： ラット ,  すい臓β細胞 ,  チャンネル ,  遊離ラジカル ,  仲介 ,  トルブタミド ,  脱感作