Mechanisms of Enhanced Oral Availability of CYP3A4 Substrates by Grapefruit Constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.

SCHMIEDLIN-REN P; EDWARDS D J; FITZSIMMONS M E; HE K; LOWN K S; WOSTER P M; RAHMAN A; THUMMEL K E; WATKINS P B

Art

J-GLOBAL ID：200902144226371218 Reference number：98A0023180

Mechanisms of Enhanced Oral Availability of CYP3A4 Substrates by Grapefruit Constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.

グレープフルーツ成分によるCYP3A4基質の経口アベイラビリティの増強機序フラノクマリン類による小腸上皮細胞のCYP3A4濃度の減少と作用機序に基づく不活性化

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Material：
Volume： 25 Issue： 11 Page： 1228-1233 Publication year： Nov. 1997
JST Material Number： H0232A ISSN： 0090-9556 Document type： Article
Article type：短報 Country of issue： United States (USA) Language： ENGLISH (EN)

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Basic biopharmacy , Enzyme physiology

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