Art

J-GLOBAL ID：200902145555298072   Reference number：98A0488538

Inhibition of Membrane-Type 1 Matrix Metalloproteinase by Hydroxamate Inhibitors: An Examination of the Subsite Pocket.

ヒドロキサム酸型阻害薬による膜1型マトリックスメタロプロテイナーゼの阻害 サブサイトポケットの検討

Author (7)： YAMAMOTO M (Kanebo Ltd., Osaka, JPN) ,  TSUJISHITA H (Kanebo Ltd., Osaka, JPN) ,  HORI N (Kanebo Ltd., Osaka, JPN) ,  OHISHI Y (Kanebo Ltd., Kanagawa, JPN) ,  INOUE S (Kanebo Ltd., Kanagawa, JPN) ,  IKEDA S (Kanebo Ltd., Osaka, JPN) ,  OKADA Y (Kanazawa Univ., Ishikawa, JPN)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 41  Issue： 8  Page： 1209-1217  Publication year： Apr. 09, 1998 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： amino acid ,...
Semi thesaurus term： molecular model

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JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Nitrogen derivatives of aliphatic carboxylic acids  (CF03220A)

Substance index (14)： Ro-31-9790 ,  Batimastat ,  Marimastat ,  GM-6001 ,  (2R)-N-[(S)-1-Phenyl-2-(methylamino)-2-oxoethyl]-N′-hydroxy-2-isobutylbutanediamide ,  N^α-[(R)-2-(Hydroxycarbamoylmethyl)-4-phenylbutyryl]-N-methyl-L-phenylglycinamide ,  N^α-[(R)-2-(Hydroxycarbamoylmethyl)-5-phenylpentanoyl]-N-methyl-L-phenylglycinamide ,  N^α-[(R)-2-(Hydroxycarbamoylmethyl)undecanoyl]-N-methyl-L-phenylglycinamide ,  (2R)-N-[(S)-1-Cyclohexyl-2-(methylamino)-2-oxoethyl]-N′-hydroxy-2-isobutylbutanediamide ,  (2R,3S)-N-[(S)-1-Phenyl-2-(methylamino)-2-oxoethyl]-N′-hydroxy-2-isobutyl-3-(morpholinomethyl)butanediamide ,  KB-8301 ,  N,3-Dimethyl-N^α-[(2R)-2-[2-oxo-2-(hydroxyamino)ethyl]-5-phenylpentanoyl]-L-valinamide ,  (2R)-N-[(S)-1-Isopropyl-2-(methylamino)-2-oxoethyl]-N′-hydroxy-2-(3-phenylpropyl)butanediamide ,  (2R,3S)-N-[(S)-1-Cyclohexyl-2-(methylamino)-2-oxoethyl]-N′-hydroxy-2-isobutyl-3-methylbutanediamide

Terms in the title (4)： ヒドロキサム酸 ,  阻害薬 ,  マトリックスメタロプロテイナーゼ ,  阻害