Art

J-GLOBAL ID：200902146328724592   Reference number：00A0808958

Synthesis and Anti-HIV Activity of 3-Alkylamido-3-deoxy-betulinic Acid Derivatives.

3-アルキルアミド-3-デオキシベツリン酸誘導体の合成及び抗HIV活性

Author (9)： KASHIWADA Y (Niigata Coll. Pharmacy, Niigata, JPN) ,  CHIYO J (Niigata Coll. Pharmacy, Niigata, JPN) ,  IKESHIRO Y (Niigata Coll. Pharmacy, Niigata, JPN) ,  NAGAO T (Fukuoka Univ., Fukuoka, JPN) ,  OKABE H (Fukuoka Univ., Fukuoka, JPN) ,  COSENTINO L M (BBI-Biotech Res. Lab., Maryland, USA) ,  FOWKE K (BBI-Biotech Res. Lab., Maryland, USA) ,  MORRIS-NATSCHKE S L (Univ. North Carolina, North Carilina, USA) ,  LEE K-H (Univ. North Carolina, North Carilina, USA)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 48  Issue： 9  Page： 1387-1390  Publication year： Sep. 01, 2000 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...

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JST classification (2)： Triterpenes  (CF10024I) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (25)： Betulic acid ,  3β-(3,3-Dimethyl-4-oxo-4-hydroxybutyryl)lupa-20(29)-ene-28-oic acid ,  3β-(3,3-Dimethyl-5-oxo-5-hydroxyvaleryl)lupa-20(29)-ene-28-oic acid ,  3β-[(2-Oxo-2-hydroxyethoxy)acetyl]lupa-20(29)-ene-28-oic acid ,  Oleanolic acid ,  3β-(3-Methyl-3-carboxybutyryl)oleana-12-ene-28-oic acid ,  Ursolic acid ,  3β-(3,3-Dimethyl-4-oxo-4-hydroxybutyryl)urs-12-ene-28-oic acid ,  Betulonic acid ,  Betulonic acid methylester ,  Betulonic acid oxime ,  3-(Hydroxyimino)lupa-20(29)-ene-28-oic acid methyl ester ,  3-(Hydroxyimino)lupa-20(29)-ene-28-oic acid phenacyl ester ,  3-(Hydroxyimino)lupa-20(29)-ene-28-oic acid allyl ester ,  3β-Aminolupa-20(29)-ene-28-oic acid methyl ester ,  3α-Aminolupa-20(29)-ene-28-oic acid methyl ester ,  3β-(3,3-Dimethyl-5-oxo-5-hydroxyvalerylamino)lupa-20(29)-ene-28-oic acid methyl ester ,  3α-(3,3-Dimethyl-5-oxo-5-hydroxyvalerylamino)lupa-20(29)-ene-28-oic acid methyl ester ,  3-Oxolupa-20(29)-ene-28-oic acid 4-morpholinecarboxylic anhydride ,  3β-(3,3-Dimethyl-5-oxo-5-hydroxyvalerylamino)lupa-20(29)-ene-28-oic acid ,  3β-(3,3-Dimethyl-4-oxo-4-hydroxybutyrylamino)lupa-20(29)-ene-28-oic acid ,  3β-[(2-Oxo-2-hydroxyethoxyacetyl)amino]lupa-20(29)-ene-28-oic acid ,  3α-(3,3-Dimethyl-5-oxo-5-hydroxyvalerylamino)lupa-20(29)-ene-28-oic acid ,  3α-(3,3-Dimethyl-4-oxo-4-hydroxybutyrylamino)lupa-20(29)-ene-28-oic acid ,  3α-[(2-Oxo-2-hydroxyethoxyacetyl)amino]lupa-20(29)-ene-28-oic acid

Reference (8)：

• 1) Xie L., Takeuchi Y., Cosentino L.M., McPhail A.T., Lee K.H., J. Med. Chem.
• 2) Fujioka T., Kashiwada Y., Kilkuskie R.E., Cosentino L.M., Ballas L.M., Jiang J.B., Janzen W.P., Chen I.S., Lee K.H., J. Nat. Prod., 57, 243 (1994).
• 3) Kashiwada Y., Hashimoto F., Cosentino L.M., Chen C.H., Garrett P.E., Lee K.H., J Med. Chem., 39, 1016 (1996).
• 4) Hashimoto F., Kashiwada Y., Cosentino L.M., Chen C.H., Garrett P.E., Lee K.H., Bioorg. Med. Chem., 5, 2133.(1997).
• 5) Kashiwada Y., Wang H.K., Nagao T., Kitanaka S., Yasuda I., Fujioka T., Yamagishi T., Cosentino L.M., Kozuka M., Okabe H., Ikeshiro Y., Hu C.Q., Yeh E., Lee K.H., J. Nat. Prod., 61, 1090 (1998).

Terms in the title (3)： 酸 ,  誘導体 ,  抗HIV活性