Art

J-GLOBAL ID：200902148225963486   Reference number：94A0294589

Potent Gastrin-Releasing Peptide(GRP) Antagonists Derived from GRP(19-27) with a C-Terminal DProΨ[CH₂NH]Phe-NH₂ and N-Terminal Aromatic Residues.

C末端D ProΨ[CH₂NH]Phe-NH₂およびN末端芳香族残基を有するGRP(19-27)由来の活性なガストリン放出ペプチド(GRP)きっ抗薬

Author (7)： LEBAN J J (Burroughs Wellcome Co., North Carolina) ,  LANDAVAZO A (Burroughs Wellcome Co., North Carolina) ,  MCDERMED J D (Burroughs Wellcome Co., North Carolina) ,  DILIBERTO E J JR (Burroughs Wellcome Co., North Carolina) ,  JANSEN M (Burroughs Wellcome Co., North Carolina) ,  STOCKSTILL B (Burroughs Wellcome Co., North Carolina) ,  KULL F C JR (Burroughs Wellcome Co., North Carolina)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 37  Issue： 4  Page： 439-445  Publication year： Feb. 18, 1994 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： biological material analog ,...
Semi thesaurus term： GRP ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=94A0294589&from=J-GLOBAL&jstjournalNo=D0102A") }}

JST classification (1)： Basic research of drugs acting on digestive system  (GW09010Q)

Substance index (17)： BW-2258U-89 ,  N^α-(3-Phenylpropionyl)-L-His-L-Trp-L-Ala-L-Val-Sar-L-His-D-Proψ(CH₂NH)-L-Phe-NH₂ ,  N^α-(3-Phenylpropionyl)-L-His-L-Trp-L-Alaψ(CH₂NH)-L-Val-D-Ala-L-His-D-Proψ(CH₂NH)-L-Phe-NH₂ ,  N^α-(3-Phenylpropionyl)-L-His-L-Trp-L-Ala-L-Val-D-Ala-L-His-L-Sta-L-Phe-NH₂ ,  N-(3-Phenylpropionyl)-L-Thi-L-Ala-L-Trp-L-Ala-L-Val-D-Ala-L-His-D-Proψ(CH₂NH)-L-Phe-NH₂ ,  N^α-[(R)-2-Phenylpropionyl]-L-His-L-Trp-L-Ala-L-Val-D-Ala-L-His-D-Proψ(CH₂NH)-L-Phe-NH₂ ,  N^α-[(S)-2-Phenylpropionyl]-L-His-L-Trp-L-Ala-L-Val-D-Ala-L-His-D-Proψ(CH₂NH)-L-Phe-NH₂ ,  BW-1023U-90 ,  N^α-[3-(4-Methoxyphenyl)propionyl]-L-His-L-Trp-L-Ala-L-Val-D-Ala-L-His-D-Proψ(CH₂NH)-L-Phe-NH₂ ,  N^α-[3-(3,4,5-Trimethoxyphenyl)propionyl]-L-His-L-Trp-L-Ala-L-Val-D-Ala-L-His-D-Proψ(CH₂NH)-L-Phe-NH₂ ,  N^α-[3-[3-(Trifluoromethyl)phenyl]propionyl]-L-His-L-Trp-L-Ala-L-Val-D-Ala-L-His-D-Proψ(CH₂NH)-L-Phe-NH₂ ,  N^α-[[2-(Trifluoromethyl)phenyl]acetyl]-L-His-L-Trp-L-Ala-L-Val-D-Ala-L-His-D-Proψ(CH₂NH)-L-Phe-NH₂ ,  N^α-[[3-(Trifluoromethyl)phenyl]acetyl]-L-His-L-Trp-L-Ala-L-Val-D-Ala-L-His-D-Proψ(CH₂NH)-L-Phe-NH₂ ,  N^α-[[4-(Trifluoromethyl)phenyl]acetyl]-L-His-L-Trp-L-Ala-L-Val-D-Ala-L-His-D-Proψ(CH₂NH)-L-Phe-NH₂ ,  N^α-(2-Phenylisobutyryl)-L-His-L-Trp-L-Ala-L-Val-D-Ala-L-His-D-Proψ(CH₂NH)-L-Phe-NH₂ ,  N^α-(3-Phenylisovaleryl)-L-His-L-Trp-L-Ala-L-Val-D-Ala-L-His-D-Proψ(CH₂NH)-L-Phe-NH₂ ,  N^α-(1-Naphthoyl)-L-His-L-Trp-L-Ala-L-Val-D-Ala-L-His-D-Proψ(CH₂NH)-L-Phe-NH₂

Terms in the title (9)： C末端 ,  PRO ,  N末端 ,  芳香族 ,  残基 ,  GRP ,  活性 ,  ガストリン放出ペプチド ,  きっ抗薬