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J-GLOBAL ID：200902149010953729   Reference number：02A0610457

Lowered response threshold and increased responsiveness to mechanical stimulation of cutaneous nociceptive fibers in streptozotocin-diabetic rat skin in vitro. Correlates of mechanical allodynia and hyperalgesia observed in the early stage of diabetes.

in vitroでのストレプトゾトシン糖尿病ラット皮膚の皮内痛覚受容線維の機械的刺激に対する応答しきい値の低下と応答増大 糖尿病初期段階で観察される機械的異痛症および痛覚過敏との相関

Author (4)： SUZUKI Y (Fujita-Health Univ., Nagoya, JPN) ,  SATO J (Nagoya Univ., Nagoya, JPN) ,  KAWANISHI M (Fujita-Health Univ., Nagoya, JPN) ,  MIZUMURA K (Nagoya Univ., Nagoya, JPN)
Material： Neuroscience Research  (神経科学)
Volume： 43  Issue： 2  Page： 171-178  Publication year： Jun. 2002 
JST Material Number： D0210C  ISSN： 0168-0102  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： streptozotocin-induced diabetes ,...

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JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Peripheral nervous system  (EJ12020U)

Reference (32)：

• AHLGREN, S. C. Mechanical hyperalgesia in streptozotocin-diabetic rats. Neuroscience. 1993, 52, 1049-1055
• AHLGREN, S. C. Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat. J. Neurophysiol. 1994, 72, 684-692
• AHLGREN, S. C. Increased responsiveness of sensory neurons in the saphenous nerve of the streptozotocin-diabetic rat. J. Neurophysiol. 1992, 68, 2077-2085
• ANDREW, D. Mechanical and heat sensitization of cutaneous nociceptors after peripheral inflammation in the rat. J. Neurophysiol. 1999, 82, 2649-2656
• ARCHER, A. G. The natural history of acute painful neuropathy in diabetes mellitus. J. Neurol. Neurosurg. Psychiatry. 1983, 46, 491-499

Terms in the title (14)： ストレプトゾトシン糖尿病 ,  ラット ,  皮膚 ,  痛覚 ,  受容 ,  機械的刺激 ,  応答 ,  しきい値 ,  糖尿病 ,  初期段階 ,  観察 ,  機械的異痛症 ,  痛覚過敏 ,  相関