Art

J-GLOBAL ID：200902152031980174   Reference number：02A0283923

Effect of Acerola Cherry Extract on Cell Proliferation and Activation of Ras Signal Pathway at the Promotion Stage of Lung Tumorigenesis in Mice.

マウスの肺腫りゅう形成のプロモーション段階における細胞増殖及びRas細胞情報伝達系の活性化に及ぼすアセロラ抽出物の影響

Author (8)： NAGAMINE I (Nihon Univ., Kanagawa, JPN) ,  AKIYAMA T (Nihon Univ., Kanagawa, JPN) ,  KAINUMA M (Nihon Univ., Kanagawa, JPN) ,  KUMAGAI H (Nihon Univ., Kanagawa, JPN) ,  SATOH H (National Inst. Health and Nutrition, Tokyo, JPN) ,  YAMADA K (National Inst. Health and Nutrition, Tokyo, JPN) ,  YANO T (National Inst. Health and Nutrition, Tokyo, JPN) ,  SAKURAI H (Nihon Univ., Kanagawa, JPN)
Material： Journal of Nutritional Science and Vitaminology  (Nutritional Science and Vitaminology)
Volume： 48  Issue： 1  Page： 69-72  Publication year： Feb. 2002 
JST Material Number： F0733A  ISSN： 0301-4800  CODEN： JNSVA5  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： lung tumor ,...
Semi thesaurus term： cellular signal transduction ,...

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JST classification (2)： Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Fruits and processed fruit products  (FJ11030Z)

Substance index (2)： NNK ,  Ascorbic Acid

Reference (21)：

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• HECHT, SS. Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen. Crit Rev Toxicol. 1996, 26, 163-181
• PETERSON, LA. O^6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung. Cancer Res. 1991, 51, 5557-5564
• YANO, T. The detection of chemically initiated cells having the mutation of K-ras gene at an early stage of lung carcinogenesis in mice. Anal Biochem. 1997, 244, 187-189
• YANO, T. Activation of extracellular signal-regulated kinase in lung tissues of mice treated with carcinogen. Life Sci. 1998, 64, 229-236

Terms in the title (10)： マウス ,  肺腫りゅう ,  プロモーション ,  段階 ,  細胞増殖 ,  Ras ,  細胞情報伝達 ,  活性化 ,  アセロラ ,  抽出物