Art

J-GLOBAL ID：200902152738960552   Reference number：02A0019156

Isolation and Structural Determination of Phepropeptins A, B, C, and D, New Proteasome Inhibitors, Produced by Streptomyces sp.

フェプロペプチンA,B,CおよびDの単離と構造決定,Streptomyces属が生産する新プロテアソーム阻害剤

Author (8)： SEKIZAWA R (Inst. Microbial Chemistry, Tokyo, JPN) ,  MOMOSE I (Inst. Microbial Chemistry, Tokyo, JPN) ,  KINOSHITA N (Inst. Microbial Chemistry, Tokyo, JPN) ,  NAGANAWA H (Inst. Microbial Chemistry, Tokyo, JPN) ,  HAMADA M (Inst. Microbial Chemistry, Tokyo, JPN) ,  MURAOKA Y (Inst. Microbial Chemistry, Tokyo, JPN) ,  IINUMA H (Inst. Microbial Chemistry, Tokyo, JPN) ,  TAKEUCHI T (Inst. Microbial Chemistry, Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 54  Issue： 11  Page： 874-881  Publication year： Nov. 25, 2001 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *enzyme inhibitor ,...
Semi thesaurus term： *Streptomyces ,...

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JST classification (1)： Antibiotics in general  (GX01000E)

Substance index (4)： Phepropeptin A ,  Phepropeptin B ,  Phepropeptin C ,  Phepropeptin D

Reference (13)：

• 1) RECHSTEINER, M.; L. HOFFMAN & W. DUBIEL: The multicatalytic and 26S proteases. J. Biol. Chem. 268: 6065-6068, 1993
• 2) ORLOWSKI, M.; C. CARDOZO & C. MICHAUD: Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids. Biochemistry 32: 1563-1572, 1993
• 3) HERSHKO, A. & A. CIECHANOVER: The ubiquitin system. Ann. Rev. Biochem. 67: 425-479, 1998
• 4) ICHIHARA, A. & K. TANAKA: Roles of proteasomes in cell growth. Mol. Biol. Rep. 21: 49-52, 1995
• 5) PALOMBELLA, V I; O. J. RANDO, A. L. GOLDBERG & T. MANIATIS: The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78: 773-785, 1994

Terms in the title (3)： 単離 ,  Streptomyces属 ,  プロテアソーム阻害剤