Art

J-GLOBAL ID：200902152834740741   Reference number：00A0366877

Development of a New Inhibitor of Glucosylceramide Synthase.

グルコシルセラミドシンターゼの新しい阻害剤の開発

Author (7)： JIMBO M (Seikagaku Corp., Tokyo) ,  YAMAGISHI K (Seikagaku Corp., Tokyo) ,  YAMAKI T (Sapporo Medical Univ. School of Medicine, Hokkaido) ,  NUNOMURA K (Sapporo Medical Univ. School of Medicine, Hokkaido) ,  KABAYAMA K (Hokkaido Univ., Hokkaido) ,  IGARASHI Y (Hokkaido Univ., Hokkaido) ,  INOKUCHI J (Hokkaido Univ., Hokkaido)
Material： Journal of Biochemistry  (J Biochem)
Volume： 127  Issue： 3  Page： 485-491  Publication year： Mar. 01, 2000 
JST Material Number： F0286A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *glucosyltransferase ,...
Semi thesaurus term： EC2.4.1.80

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JST classification (2)： Enzyme in general  (EB09010D) ,  Nitrogen derivatives of aromatic monocyclic carboxylic acids  (CF05200S)

Reference (22)：

• 1. Inokuchi, J. and Radin, N. S. (1987) Preparation of active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase. J. Lipid. Res. 28, 565-571
• 2. Inokuchi, J. (1987) Roles of glycosphingolipids revealed by D-PDMP, an inhibitor of glucosylceramide synthase. Trends Glycosci. Glycotechnol. 9, S37-S45
• 3. Alessandri, G., Filippeschi, S., Sinibaldi, P., Mornet, F., Passera, P., Spreafico, F., Cappa, P. M., and Gullino, P. M. (1987) Influence of gangliosides on primary and metastatic neoplastic growth in human and murine cells. Cancer Res. 47, 4243-4247
• 4. Liu, Y., Han, T. Y., Giuliano, A. E., and Cabot, M. C. (1999) Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells. J. Biol. Chem. 274, 1140-1146
• 5. Kaneda, K., Masuzawa, T., Yasugami, K, Suzuki, T., Suzuki, Y., and Yanagihara, Y. (1997) Glycosphingolipid-binding protein of Borrelia burgdorferi sensu lato. Infect. Immun. 65, 3180-3185

Terms in the title (3)： グルコシルセラミドシンターゼ ,  阻害剤 ,  開発