Art

J-GLOBAL ID：200902153281293713   Reference number：00A0425668

A Novel Tandem Michael Addition/Meerwein-Ponndorf-Verley Reduction: Asymmetric Reduction of Acyclic α,β-Unsaturated Ketones Using A Chiral Mercapto Alcohol.

新規な逐次Michael付加/Meerwein-Ponndorf-Verley還元 キラルなメルカプトアルコールを使用する非環状α,β-不飽和ケトンの不斉還元

Author (5)： NODE M (Kyoto Pharmaceutical Univ., Kyoto, JPN) ,  NISHIDE K (Kyoto Pharmaceutical Univ., Kyoto, JPN) ,  SHIGETA Y (Kyoto Pharmaceutical Univ., Kyoto, JPN) ,  SHIRAKI H (Kyoto Pharmaceutical Univ., Kyoto, JPN) ,  OBATA K (Kyoto Pharmaceutical Univ., Kyoto, JPN)
Material： Journal of the American Chemical Society  (J Am Chem Soc)
Volume： 122  Issue： 9  Page： 1927-1936  Publication year： Mar. 08, 2000 
JST Material Number： C0254A  ISSN： 0002-7863  CODEN： JACSAT  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *unsaturated ketone ,...

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JST classification (2)： Aromatic monocyclic ketones  (CF05170I) ,  Stereochemistry of organic reaction  (CF02130V)

Substance index (54)： (+)-10-Mercaptoisoborneol ,  Methyl vinyl ketone ,  Dimethylaluminum chloride ,  (4α)-1β-[[(S)-3-Hydroxybutyl]thiomethyl]-7,7-dimethylbicyclo[2.2.1]heptane-2-one ,  Benzoic acid (S)-sec-butyl ester ,  2α-(1-Methyl-1-mercaptoethyl)-5β-methylcyclohexan-1β-ol ,  (2R)-2α-[1-[[(S)-3-Hydroxybutyl]thio]-1-methylethyl]-5β-methylcyclohexane-1-one ,  (1R)-2α-[1-(3-Oxobutylthio)-1-methylethyl]-5β-methylcyclohexan-1β-ol ,  4-Phenyl-3-buten-2-one ,  1-Phenyl-1-penten-3-one ,  Propylstyryl ketone ,  1-Phenyl-1-hepten-3-one ,  1-Phenyl-1-undecene-3-one ,  Chalcone ,  4-Methoxychalcone ,  4-Methylchalcone ,  4-Methyl-3-penten-2-one ,  1-Octen-3-one ,  1-Phenyl-2-buten-1-one ,  (4α)-1β-[[(1R,3S)-1-Phenyl-3-hydroxybutyl]thiomethyl]-7,7-dimethylbicyclo[2.2.1]heptane-2-one ,  (4α)-1β-[[(1R,3S)-1-Phenyl-3-hydroxypentyl]thiomethyl]-7,7-dimethylbicyclo[2.2.1]heptane-2-one ,  (4α)-1β-[[(1R,3S)-1-Phenyl-3-hydroxyhexyl]thiomethyl]-7,7-dimethylbicyclo[2.2.1]heptane-2-one ,  (4α)-1β-[[(1R,3S)-1-Phenyl-3-hydroxyheptyl]thiomethyl]-7,7-dimethylbicyclo[2.2.1]heptane-2-one ,  (4α)-1β-[[(1R,3S)-1-Phenyl-3-hydroxydodecyl]thiomethyl]-7,7-dimethylbicyclo[2.2.1]heptane-2-one ,  (4α)-1β-[[(1R,3R)-1,3-Diphenyl-3-hydroxypropyl]thiomethyl]-7,7-dimethylbicyclo[2.2.1]heptane-2-one ,  (4α)-1β-[[(1R,3R)-1-(4-Methoxyphenyl)-3-phenyl-3-hydroxypropyl]thiomethyl]-7,7-dimethylbicyclo[2.2.1]heptane-2-one ,  (1S,4α)-1-[[(1R,3R)-1-p-Tolyl-3-phenyl-3-hydroxypropyl]thiomethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one ,  (1S,4α)-1-[[(S)-1,1-Dimethyl-3-hydroxybutyl]thiomethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one ,  (1S,4α)-1-[[(S)-3-Hydroxyoctyl]thiomethyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-one ,  (4α)-1β-[[(1S,3R)-1-Methyl-3-hydroxy-3-phenylpropyl]thiomethyl]-7,7-dimethylbicyclo[2.2.1]heptane-2-one ,  (S)-4-Phenyl-2-butanol ,  (S)-1-Phenyl-3-pentanol ,  (S)-1-Phenyl-3-hexanol ,  (S)-1-Phenyl-3-heptanol ,  (S)-1-Phenylundecane-3-ol ,  (R)-1,3-Diphenyl-1-propanol ,  (R)-1-Phenyl-3-(4-methoxyphenyl)-1-propanol ,  (R)-1-Phenyl-3-(4-methylphenyl)-1-propanol ,  Benzoic acid (S)-1,3-dimethylbutyl ester ,  Benzoic acid (S)-1-methylbutyl ester ,  Benzoic acid (R)-1-ethylhexyl ester ,  Benzoic acid (R)-1-phenylbutyl ester ,  (2S)-4-Phenyl-3-buten-2-ol ,  (S)-1-Phenyl-1-heptene-3-ol ,  (S)-1-Phenyl-1-undecene-3-ol ,  (R)-α-Styrylbenzenemethanol ,  (3aβ,6aβ)-4β-(3-Oxo-1-octenyl)-5α-(benzoyloxy)hexahydro-2H-cyclopenta[b]furan-2-one ,  (3aβ,6aβ)-4β-[(3S)-3-Hydroxy-1-octenyl]-5α-(benzoyloxy)hexahydro-2H-cyclopenta[b]furan-2-one ,  (3aβ,6aβ)-4-[(3S)-3-Hydroxyoctylidene]-5α-(benzoyloxy)hexahydro-2H-cyclopenta[b]furan-2-one ,  (4β)-1α-(Mercaptomethyl)-7,7-dimethylbicyclo[2.2.1]heptane-2β-ol ,  (4β)-1α-[[(1S,3R)-1-Phenyl-3-hydroxyundecyl]thiomethyl]-7,7-dimethylbicyclo[2.2.1]heptane-2-one ,  (R)-1-Phenylundecane-3-ol ,  (R)-4-Acetoxydodecanoic acid ,  Dodecanolactone

Terms in the title (7)： 逐次 ,  Michael付加 ,  Meerwein-Ponndorf-Verley還元 ,  キラル ,  環状 ,  不飽和ケトン ,  不斉還元