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J-GLOBAL ID:200902154155084773   Reference number:02A0270715

Oxysterol-Induced Apoptosis of Vascular Smooth Muscle Cells is Reduced by HMG-CoA Reductase Inhibitor, Pravastatin.

オキシステロールで誘導される血管平滑筋細胞のアポトーシスはHMG-CoA還元酵素阻害剤プラバスタチンで抑制される
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Volume:Issue:Page: 65-71  Publication year: 2002 
JST Material Number: L2187A  ISSN: 1340-3478  CODEN: JATHEH  Document type: Article
Article type: 原著論文  Country of issue: Japan (JPN)  Language: ENGLISH (EN)
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Basic research of drugs acting on lipid metabolism 
Reference (34):
  • (1) Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, Macfarlane PW, Mckillop JH, and Packard CJ: Prevention of corony heart disease with pravastatin in men with hypercholesterolemia. N Engl J MED, 333: 1301-1307, 1995
  • (2) Pitt B, Mancini GB, Ellis SG, Rosman HS, Park JS, and McGovern ME: Pravastatin limitation of atherosclerosis in the coronary arteries (PLAC-1): reduction in atherosclerosis progression and clinical events. PLAC-1 investigation. J Am Coll Cardiol, 26: 1133-1139, 1995
  • (3) Byington RP, Furberg CD, Crouse JR 3rd, Espeland MA, and Bond MG: Pravastatin, Lipids, and atherosclerosis in the catotid arteries (PLAC-II). Am J Cardiol, 76: 54C-59C, 1995
  • (4) Salonen R, Nyyssonen K, Porkkala E, Rummukainen J, Belder R, Park JS, and Salonen JT: Kupio atherosclerosis prevention study (KAPS). A population-based primary preventive trial of the effect of LDL lowering on atherosclerotic progression in carotid and femoral arteries. Circulation, 92: 1758-1764, 1995
  • (5) Gaw A: Can the clinical efficacy of the HMG CoA reductase inhibitors be explained solely by their effects on LDL-cholesterol ?. Atherosclerosis, 125: 267-269, 1996
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