Art

J-GLOBAL ID：200902154516286821   Reference number：99A0058750

Synthesis of Peptide Aldehyde Derivatives as Selective Inhibitors of Human Cathepsin L and Their Ingibitory Effect on Bone Resorption.

ヒトのカテプシンLの選択的な阻害剤としてのペプチドアルデヒド誘導体の合成と,骨吸収に対するその阻害作用

Author (8)： YASUMA T (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  OI S (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  CHOH N (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  NOMURA T (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  FURUYAMA N (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  NISHIMURA A (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  FUJISAWA Y (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  SOHDA T (Takeda Chemical Ind. Ltd., Osaka, JPN)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 41  Issue： 22  Page： 4301-4308  Publication year： Oct. 22, 1998 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： nitrogen heterocyclic compound ,...

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JST classification (2)： Basic research of other drugs acting on metabolism  (GW13060I) ,  Condensed derivatives of pyrroles  (CF07077C)

Substance index (30)： (S)-2-[[(2S,3R)-2-(tert-Butoxycarbonylamino)-3-methylpentanoyl]amino]-3-(1H-indole-3-yl)propanal ,  (S)-α-[[(2S,3R)-2-(Benzyloxycarbonylamino)-3-methylpentanoyl]amino]-1H-indole-3-propanal ,  (S)-α-[[(2S,3R)-2-[3-(3-Methylphenyl)ureido]-3-methylpentanoyl]amino]-1H-indole-3-propanal ,  (S)-α-[[(2S,3R)-2-(3-Benzylureido)-3-methylpentanoyl]amino]-1H-indole-3-propanal ,  (S)-α-[[(2S,3R)-2-(3-Isopropylureido)-3-methylpentanoyl]amino]-1H-indole-3-propanal ,  (S)-α-[[(2S,3R)-2-[3-[2-(Trifluoromethyl)phenyl]ureido]-3-methylpentanoyl]amino]-1H-indole-3-propanal ,  (S)-α-[[(2S,3R)-2-[3-(1-Naphthyl)ureido]-3-methylpentanoyl]amino]-1H-indole-3-propanal ,  (S)-α-[[(2S,3R)-2-(3-Benzylthioureido)-3-methylpentanoyl]amino]-1H-indole-3-propanal ,  (S)-α-[[(2S,3R)-2-[3-(1-Naphthyl)thioureido]-3-methylpentanoyl]amino]-1H-indole-3-propanal ,  (S)-α-[[(2S,3R)-2-(3-Phenylthioureido)-3-methylpentanoyl]amino]-1H-indole-3-propanal ,  (S)-α-[[(2S,3R)-2-(4-Methylphenylsulfonylamino)-3-methylpentanoyl]amino]-1H-indole-3-propanal ,  (S)-α-[[(2S,3R)-2-(1-Naphthylsulfonylamino)-3-methylpentanoyl]amino]-1H-indole-3-propanal ,  (S)-α-[[(2S,3R)-2-(2-Naphthylsulfonylamino)-3-methylpentanoyl]amino]-1H-indole-3-propanal ,  (S)-α-[[(2S,3R)-2-(Benzoylamino)-3-methylpentanoyl]amino]-1H-indole-3-propanal ,  (S)-α-[N-(1-Naphthylsulfonyl)-L-leucylamino]-1H-indole-3-propanal ,  (S)-α-[N-(1-Naphthylsulfonyl)-L-alanylamino]-1H-indole-3-propanal ,  (S)-α-[N-(1-Naphthylsulfonyl)-L-valylamino]-1H-indole-3-propanal ,  (S)-α-[N-(1-Naphthylsulfonyl)-L-phenylalanylamino]-1H-indole-3-propanal ,  (S)-α-[3-(Methoxycarbonyl)-2-[(1-naphthylsulfonyl)amino]propionylamino]-1H-indole-3-propanal ,  (S)-α-[N-(1-Naphthylsulfonyl)glycylamino]-1H-indole-3-propanal ,  (S)-3-Phenyl-2-[[N-(1-naphthylsulfonyl)isoleucyl]amino]propanal ,  (2S)-2-[[(1-Naphthylsulfonyl)-L-Ile-]amino]-3-(4-hydroxyphenyl)propanal ,  (S)-4-Methyl-2-[[N-(1-naphthylsulfonyl)isoleucyl]amino]pentanal ,  (S)-3-Methyl-2-[[N-(1-naphthylsulfonyl)isoleucyl]amino]butanal ,  (S)-2-[[N-(1-Naphthylsulfonyl)isoleucyl]amino]propanal ,  2-[[N-(1-Naphthylsulfonyl)isoleucyl]amino]ethanal ,  (S)-α-[(Benzyloxycarbonyl)amino]-1H-indole-3-propanal ,  (S)-α-[(3-Phenylpropionyl)amino]-1H-indole-3-propanal ,  (S)-α-[(Cyclohexylcarbonyl)amino]-1H-indole-3-propanal ,  (S)-α-(2-Propylpentanoylamino)-1H-indole-3-propanal

Terms in the title (6)： ヒト ,  カテプシンL ,  阻害剤 ,  誘導体 ,  骨吸収 ,  阻害作用