Phenyioin and Its Metabolite, 5-(4-Hydroxyphenyl)-5-Phenylhydantoin, Show Bone Resorption in Cultured Neonatal Mouse Calvaria.

TAKAHASHI A; ONODERA K; SHINODA H; MAYANAGI H

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J-GLOBAL ID：200902155345464820 Reference number：00A0560088

Phenyioin and Its Metabolite, 5-(4-Hydroxyphenyl)-5-Phenylhydantoin, Show Bone Resorption in Cultured Neonatal Mouse Calvaria.

フェニトインとその代謝産物5-(4-ヒドロキシフェニル)-5-フェニルヒダントインはマウス新生児培養頭蓋冠骨における骨吸収を示す

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Volume： 82 Issue： 1 Page： 82-84 Publication year： Jan. 01, 2000
JST Material Number： G0813A ISSN： 0021-5198 CODEN： JJPAA Document type： Article
Article type：短報 Country of issue： Japan (JPN) Language： ENGLISH (EN)

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Basic research of antiepileptics and anticonvulsants

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RICHENS, A. Disturbance of calcium metabolism by anticonvulsant drugs. Br Med J. 1970, 4, 73-76
KAMALI, F. Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowth. J Periodont Res. 1999, 34, 145-153
ONODERA, K. Phenytoin-induced osteopenia and its prevention with 1α(OH)D_3 or 1α,25(OH)_2D_3 in rats. Tohoku Univ Dent J. 1998, 17, 84-91
KRUSE, K. On the pathogenesis of anticonvulsant-drug-induced alterations of calcium metabolism. Eur J Pediatr. 1982, 138, 202-205

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