Art

J-GLOBAL ID：200902159461363912   Reference number：99A0324899

(-)-Phenylahistin Arrests Cells in Mitosis by Inhibiting Tubulin Polymerization.

(-)-フェニラヒスチンはチューブリンの重合抑制によって,有糸分裂細胞の成長を阻止する

Author (5)： KANOH K (Nippon Steel Corp., Kawasaki, JPN) ,  KOHNO S (Nippon Steel Corp., Kawasaki, JPN) ,  KATADA J (Nippon Steel Corp., Kawasaki, JPN) ,  TAKAHASHI J (Nippon Steel Corp., Kawasaki, JPN) ,  UNO I (Nippon Steel Corp., Kawasaki, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 52  Issue： 2  Page： 134-141  Publication year： Feb. 1999 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cytotoxicity ,...
Semi thesaurus term： Aspergillus ,...

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JST classification (1)： Pharmacology of antibiotics in general  (GX05010R)

Substance index (1)： (-)-Phenylahistin

Reference (26)：

• 1) WEISENBERG, R. C; G. G. BORISY & E. W. TAYLOR: The colchicine binding protein of mammalian brain and its relation to micro tubules. Biochemistry 7: 4466-4479, 1968
• 2) KANOH, K.; S. KOHNO, T. ASARI, T. HARADA, J. KATADA, M. MURAMATSU, H. KAWASHIMA, H. SEKIYA & I. UNO: (-)-Phenylahistin: A new mammalian cell cycle inhibitor produced by Aspergillus ustus. Bioorg. Med. Chem. Lett 7:2847-2852, 1997
• 3) YAMORI, T.: A human cell line panel for screening anticancer drugs. Jpn. J. Cancer Chemother. (Japanese) 24: 129-135, 1997
• 4) AHMED, S. A.; R. M. Jr. GOGAL & J. E. WALSH: A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [³H]thymidine incorporation assay. J. Immunol. Methods 170: 211-224, 1994
• 5) YAHARA, I. & F. KAKIMOTO-SAMESHIMA: Microtubule organization of lymphocytes and its modulation by patch and cap formation. Cell 15: 251-259, 1978

Terms in the title (7)： フェニラヒスチン ,  チューブリン ,  重合抑制 ,  有糸分裂 ,  細胞 ,  成長 ,  阻止