Antitumor Activity of a Novel Quinoline Derivative, TAS-103, with Inhibitory Effects on Topoisomerases I and II.

UTSUGI T; AOYAGI K; ASANO T; OKAZAKI S; AOYAGI Y; SANO M; WIRZBA K; YAMADA Y

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J-GLOBAL ID：200902160723956063 Reference number：98A0017094

Antitumor Activity of a Novel Quinoline Derivative, TAS-103, with Inhibitory Effects on Topoisomerases I and II.

トポイソメラーゼIおよびIIに阻害効果を持つ新しいキノン誘導体TAS-103の抗腫よう活性

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Material：
Volume： 88 Issue： 10 Page： 992-1002 Publication year： Oct. 1997
JST Material Number： F0633A ISSN： 0910-5050 Document type： Article
Article type：原著論文 Country of issue： Japan (JPN) Language： ENGLISH (EN)

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Basic research of antitumor(=antineoplastic)drugs , Basic research of enzyme preparations and enzyme inhibitor preparations

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Reference (42)：

WANG, J. C. DNA topoisomerases. Annu. Rev. Biochem. 1996, 65, 635-692
OSHEROFF, N. Biochemical basis for the interactions of type I and type II topoisomerases with DNA. Pharmacol. Ther. 1989, 41, 223-241
DAVIES, S. M. Nuclear topoisomerase II levels correlate with the sensitivity of mammalian cells to intercalating agents and epipodophyllotoxins. J. Biol. Chem. 1988, 263, 17724-17729
DEFFIE, A. M. Direct correlation between DNA topoisomerase II activity and cytotoxicity in Adriamycin-sensitive and -resistant P388 leukemia cell lines. Cancer Res. 1989, 49, 58-62
BJORNSTI, M. -A. Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin. Cancer Res. 1989, 49, 6318-6323

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