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J-GLOBAL ID：200902163128449165   Reference number：00A0114101

Structural Conversion from Non-native to Native form of Recombinant Human Epidermal Growth Factor by Brevibacillus choshinensis.

Brevibacillus choshinensisによる組換えヒト上皮細胞増殖因子の非天然型から天然型への構造変換

Author (8)： MIYAUCHI A (Higeta Shoyu Co., Ltd., Chiba, JPN) ,  OZAWA M (Higeta Shoyu Co., Ltd., Chiba, JPN) ,  MIZUKAMI M (Higeta Shoyu Co., Ltd., Chiba, JPN) ,  YASHIRO K (Higeta Shoyu Co., Ltd., Chiba, JPN) ,  EBISU S (Higeta Shoyu Co., Ltd., Chiba, JPN) ,  TOJO T (Higeta Shoyu Co., Ltd., Chiba, JPN) ,  FUJII T (Chiba Univ., Chiba, JPN) ,  TAKAGI H (Higeta Shoyu Co., Ltd., Chiba, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 63  Issue： 11  Page： 1965-1969  Publication year： Nov. 23, 1999 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Bacillus brevis ,...
Semi thesaurus term： deactivation

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JST classification (2)： Microbial metabolite production  (FK03020A) ,  Microorganism biochemistry  (EG03020N)

Substance index (2)： Glutathione ,  Cysteine

Reference (17)：

• 1) Udaka, S. and Yamagata, H., High-level secretion of heterologus proteins by Bacillus brevis, In “Methods in Enzymology,” ed. Klinman, J. P., Vol. 217, Academic press, Inc., New York, pp. 23-33 (1993).
• 2) Takagi, H., Kadowaki, K., and Udaka, S., Screening and characterization of protein-hyper producing bacteria without detectable exoprotease activity. Agric. Biol. Chem., 53, 691-699 (1989).
• 3) Shida, O., Takagi, H., Kadowaki, K., and Komagata, K., Proposal for two new genera, Brevibacillus gen nov and Aneurinibacillus gen nov. Int. J. Syst. Bacteriol., 46, 939-946 (1996).
• 4) Miyauchi, A., Ebisu, S., Uchida, K., Yoshida, M., Ozawa, M., Tojo, T., Kadowaki, K., and Takagi, H., Pilot scale production of a recombinant human epidermal growth factor, secreted by Bacillus brevis, using expanded bed adsorption. J. Indust. Microbiol. Biotech., 21, 208-214 (1998).
• 5) Creighton, T. E., Hillson, D. A. and Freedman, R. B., Catalysis by protein-disulphide isomerase of the unfolding and refolding of proteins with disulphide bonds. J. Mol. Biol., 142, 43-62 (1980).

Terms in the title (4)： Brevibacillus ,  組換え ,  ヒト ,  上皮細胞増殖因子