Art

J-GLOBAL ID：200902163322531719   Reference number：02A0707462

Advantages of in vitro cytotoxicity testing by using primary rat hepatocytes in comparison with established cell lines.

確立細胞株と比較したラット初代肝細胞を用いたin vitro細胞毒性テストの長所

Author (4)： WANG K (Dalian Medical Univ., Dalian, CHN) ,  SHINDOH H (Nippon Roche Res. Center, Kanagawa, JPN) ,  INOUE T (Nippon Roche Res. Center, Kanagawa, JPN) ,  HORII I (Nippon Roche Res. Center, Kanagawa, JPN)
Material： Journal of Toxicological Sciences  (日本毒性学会学術年会プログラム・要旨集)
Volume： 27  Issue： 3  Page： 229-237  Publication year： Aug. 2002 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cytotoxicity ,...
Semi thesaurus term： non-steroidal anti-inflammatory agent ,...

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JST classification (2)： Toxicology in general  (GZ01000K) ,  Cell and tissue culture methods  (EA03040R)

Substance index (15)： Acetaminophen ,  Amiodarone ,  Cyclophosphamid ,  Phenytoin ,  Isoniazide ,  Erythromycin ,  Ketoconazole ,  Disulfiram ,  Aspirin ,  Lithocholic Acid ,  Diclophenac sodium ,  Thioacetamide ,  Chlorpromazine hydrochloride ,  Quinidine ,  Clofibric acid

Reference (45)：

• Albano, E., Rundrgren, M., Harvison, P.J., Nelson, S.D. and Moldeus, P. (1985): Mechanisms of N-acetyl-p-benzo-quinone imine cytotoxicity. Mol. Pharmacol., 28, 306-311.
• Allen, K.J., Reyes, R., Demmler, K., Mercer, J.F., Williamson, R. and Whitehead, R.H. (2000): Conditionally immortalized mouse hepatocytes for use in liver gene therapy. J. Gastroenterol. Hepatology, 15, 1325-1332.
• Baur, H. and Heldt, H.W. (1977): Transport of hexoses across the liver cell membrane. Eur. J. Biochem., 74, 397-403.
• Begue, J.M., Guguen-Guillouzo, C., Pasdeloup, N. and Guillouzo, A. (1984): Prolonged maintenance of active cytochrome P-450 in adult rat hepatocytes co-culture with another liver cell type. Hepatology, 4, 839-842.
• Bort, R., Ponsoda, X., Jover, R., Gomez-Lechon, J. and Castell, J.V. (1999): Diclofenac toxicity to hepatocytes: A role for drug metabolism in cell toxicity. J. Pharmacol. Exp. Ther., 288, 65-72.

Terms in the title (6)： 細胞株 ,  ラット ,  初代肝細胞 ,  細胞毒性 ,  テスト ,  長所