Art

J-GLOBAL ID：200902164247295440   Reference number：01A0484911

2- and 3-Substituted 1,4-Naphthoquinone Derivatives as Subversive Substrates of Trypanothione Reductase and Lipoamide Dehydrogenase from Trypanosoma cruzi: Synthesis and Correlation between Redox Cycling Activities and in Vitro Cytotoxicity.

Trypanosoma cruziからのトリパノチオンレダクターゼ及びリポアミドデヒドロゲナーゼの破壊的基質としての2-及び3-置換1,4-ナフトキノン誘導体 合成及びレドックスサイクリング活性とin vitro細胞毒性との相関

Author (9)： SALMON-CHEMIN L (Univ. Lille II, Lille, FRA) ,  BUISINE E (Univ. Lille II, Lille, FRA) ,  YARDLEY V (London School of Hygiene & Tropical Medicine, London, GBR) ,  KOHLER S (Univ. Heidelberg, Heidelberg, DEU) ,  LANDRY V (Univ. Lille II, Lille, FRA) ,  SERGHERAERT C (Univ. Lille II, Lille, FRA) ,  CROFT S L (London School of Hygiene & Tropical Medicine, London, GBR) ,  KRAUTH-SIEGEL R L (Univ. Heidelberg, Heidelberg, DEU) ,  DAVIOUD-CHARVET E (Univ. Lille II, Lille, FRA)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 44  Issue： 4  Page： 548-565  Publication year： Feb. 15, 2001 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *quinone ,...
Semi thesaurus term： NADH oxidoreductase ,...

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JST classification (2)： Basic research of antiprotozoan drugs and anthelmintics  (GW17080G) ,  Naphthalenes  (CF06020D)

Substance index (22)： Menadione ,  2-Methyl-3-[3-[4-(3-aminopropyl)piperazino]propylamino]-1,4-naphthoquinone ,  2-Methyl-3-[3-[4-(3-aminopropyl)piperazino]propylamino]-5-hydroxy-1,4-naphthoquinone ,  2-Methyl-3-[3-(3-aminopropylamino)propylamino]-1,4-naphthoquinone ,  2-Methyl-3-[3-(3-aminopropylamino)propylamino]-5-hydroxy-1,4-naphthoquinone ,  2-Methyl-3-[3-[4-(3-aminopropylamino)butylamino]propylamino]-1,4-naphthoquinone ,  2-Methyl-3-[3-[4-(3-aminopropylamino)butylamino]propylamino]-5-hydroxy-1,4-naphthoquinone ,  2-Methyl-3-(4-aminobutylamino)-1,4-naphthoquinone ,  2-Methyl-3-(4-aminobutylamino)-5-hydroxy-1,4-naphthoquinone ,  2-Methyl-3-[3-(4-methylpiperazino)propylamino]-1,4-naphthoquinone ,  2-Methyl-3-[3-(4-methylpiperazino)propylamino]-5-hydroxy-1,4-naphthoquinone ,  2-[4-[3-(Dimethylamino)propyl]piperazinomethyl]-3-[4-[3-(dimethylamino)propyl]piperazino]-1,4-naphthoquinone ,  2,2′-[Piperazine-1,4-diylbis(trimethyleneimino)]bis(3-methyl-1,4-naphthoquinone) ,  2,2′-[Iminobis(trimethyleneimino)]bis(3-methyl-1,4-naphthoquinone) ,  2,2′-[Tetramethylenebis(iminotrimethyleneimino)]bis(3-methyl-1,4-naphthoquinone) ,  2,2′-(Tetramethylenebisimino)bis(3-methyl-1,4-naphthoquinone) ,  2-Methyl-3-[2-[3-(4-methylpiperazino)propylcarbamoyl]ethyl]-1,4-naphthoquinone ,  2-Methyl-3-[2-[3-(4-methylpiperazino)propylcarbamoyl]ethyl]-5-hydroxy-1,4-naphthoquinone ,  2-Methyl-3-[3-[3-(4-methylpiperazino)propylcarbamoyl]propyl]-1,4-naphthoquinone ,  2-Methyl-3-[3-[3-(4-methylpiperazino)propylcarbamoyl]propyl]-5-hydroxy-1,4-naphthoquinone ,  Plumbagin ,  5-Hydroxy-1,4-naphthoquinone

Terms in the title (10)： Trypanosoma ,  トリパノチオンレダクターゼ ,  リポアミドデヒドロゲナーゼ ,  破壊 ,  基質 ,  置換 ,  ナフトキノン誘導体 ,  活性 ,  細胞毒性 ,  相関