Art

J-GLOBAL ID：200902164975846657   Reference number：00A0148703

Design and Synthesis of Highly Potent Fumagillin Analogues from Homology Modeling for a Human MetAP-2.

ヒトMetAP-2のホモロジーモデル化由来の高度に強力なフマギリン類似体の設計と合成

Author (9)： HAN C K (Chong Kun Dang Res. Inst., Chungcheongnamdo, KOR) ,  AHN S K (Chong Kun Dang Res. Inst., Chungcheongnamdo, KOR) ,  CHOI N S (Chong Kun Dang Res. Inst., Chungcheongnamdo, KOR) ,  HONG R K (Chong Kun Dang Res. Inst., Chungcheongnamdo, KOR) ,  MOON S K (Chong Kun Dang Res. Inst., Chungcheongnamdo, KOR) ,  CHUN H S (Chong Kun Dang Res. Inst., Chungcheongnamdo, KOR) ,  LEE S J (Chong Kun Dang Res. Inst., Chungcheongnamdo, KOR) ,  KIM D (Seoul National Univ., Seoul, KOR) ,  NO K T (Soong Sil Univ., Seoul, KOR)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 10  Issue： 1  Page： 39-43  Publication year： Jan. 03, 2000 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...

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JST classification (3)： Three-membered heterocyclic compounds  (CF07050R) ,  Synthesis of antibiotics  (GX04000Z) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (16)： TNP-470 ,  CKD-731 ,  (2E,4E)-2,4-Hexadienoic acid (3R)-4β-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5α-methoxy-1-oxaspiro[2.5]octane-6α-yl ester ,  trans-Cinnamic acid (3R)-4β-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5α-methoxy-1-oxaspiro[2.5]octane-6α-yl ester ,  4-Methoxycinnamic acid (3R)-4β-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5α-methoxy-1-oxaspiro[2.5]octane-6α-yl ester ,  4-Methoxy-cis-cinnamic acid (3R)-4β-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5α-methoxy-1-oxaspiro[2.5]octane-6α-yl ester ,  3-(3,4,5-Trimethoxyphenyl)propionic acid (3R)-4β-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5α-methoxy-1-oxaspiro[2.5]octane-6α-yl ester ,  Benzylcarbamic acid (3R)-4β-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5α-methoxy-1-oxaspiro[2.5]octane-6α-yl ester ,  (4-Methoxybenzyl)carbamic acid (3R)-4β-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5α-methoxy-1-oxaspiro[2.5]octane-6α-yl ester ,  [4-(Trifluoromethyl)benzyl]carbamic acid (3R)-4β-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5α-methoxy-1-oxaspiro[2.5]octane-6α-yl ester ,  (3,4-Dimethoxyphenethyl)carbamic acid (3R)-4β-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5α-methoxy-1-oxaspiro[2.5]octane-6α-yl ester ,  Carbonic acid (3R)-4β-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5α-methoxy-1-oxaspiro[2.5]octane-6α-yl 4-methoxybenzyl ester ,  Carbonic acid (3R)-4β-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5α-methoxy-1-oxaspiro[2.5]octane-6α-yl 4-nitrobenzyl ester ,  Carbonic acid (3R)-4β-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5α-methoxy-1-oxaspiro[2.5]octane-6α-yl 4-methoxyphenethyl ester ,  Dithiocarbonic acid O-[(3R)-4β-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5α-methoxy-1-oxaspiro[2.5]octane-6α-yl]S-benzyl ester ,  4-(4-Methoxyphenyl)butyric acid (3R)-4β-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-5α-methoxy-1-oxaspiro[2.5]octane-6α-yl ester

Terms in the title (5)： ヒト ,  ホモロジーモデル ,  フマギリン ,  類似体 ,  設計