Art

J-GLOBAL ID：200902166253646508   Reference number：03A0087570

Total Synthesis of (±)-Wortmannin.

(±)-ウォルトマンニンの全合成

Author (4)： MIZUTANI T (Univ. Tokyo, Tokyo, JPN) ,  HONZAWA S (Univ. Tokyo, Tokyo, JPN) ,  TOSAKI S (Univ. Tokyo, Tokyo, JPN) ,  SHIBASAKI M (Univ. Tokyo, Tokyo, JPN)
Material： Angewandte Chemie. International Edition  (Angewandte Chemie. International Edition in English)
Volume： 41  Issue： 24  Page： 4680-4682  Publication year： Dec. 16, 2002 
JST Material Number： H0127B  ISSN： 1433-7851  CODEN： ACIEAY  Document type： Article
Article type： 短報  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： heterosteroid ,...
Semi thesaurus term： Penicillium ,...

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JST classification (2)： Condensed derivatives of pyrane  (CF07093I) ,  Enzyme in general  (EB09010D)

Substance index (20)： Wortmannin ,  1α-(Methoxymethyl)-11α-(tert-butyldimethylsiloxy)-6,7-[methoxymethylenebis(oxy)]-17,17-[ethylenebis(oxy)]-2-oxa-5α-androsta-8-ene-3-one ,  (1E)-2-(Benzyloxy)-11β-[[2-(trimethylsilyl)ethoxy]methoxy]-17,17-[ethylenebis(oxy)]-5-desethyl-2,3-secoandrosta-1,8-diene ,  (3aS,6S,7aS)-4-[(4Z)-4-Methyl-6-(benzyloxy)-4-hexenyl]-5-(trifluoromethylsulfonyloxy)-6-[[2-(trimethylsilyl)ethoxy]methoxy]-7a-methyl-3a,6,7,7a-tetrahydrospiro[indan-1,2′-[1,3]dioxolane] ,  (3aα,4S)-1,5-Dioxo-7aβ-methylhydrindane-4α-carboxylic acid methyl ester ,  (3aS)-4-Allyl-5-[(trifluoromethyl)sulfonyloxy]-6β-hydroxy-7aβ-methyl-2,3,3aα,6,7,7a-hexahydrospiro[1H-indene-1,2′-[1,3]dioxolane] ,  (3aS)-4-Allyl-5-[(trifluoromethyl)sulfonyloxy]-6β-[[2-(trimethylsilyl)ethoxy]methoxy]-7aβ-methyl-2,3,3aα,6,7,7a-hexahydrospiro[1H-indene-1,2′-[1,3]dioxolane] ,  (Z)-1-(Benzyloxy)-3-iodo-2-butene ,  (1E)-2-(Benzyloxy)-11α-hydroxy-17,17-[ethylenebis(oxy)]-5-desethyl-2,3-secoandrosta-1,8-diene ,  (1S)-1,2-Dihydroxy-11α-(tert-butyldimethylsiloxy)-17,17-[ethylenebis(oxy)]-5-desethyl-2,3-secoandrosta-8-ene ,  (1S)-1-Acetoxy-2-methoxy-11α-(tert-butyldimethylsiloxy)-17,17-[ethylenebis(oxy)]-5-desethyl-2,3-secoandrosta-8-ene ,  (1S)-1-Acetoxy-2-methoxy-11α-(tert-butyldimethylsiloxy)-17,17-[ethylenebis(oxy)]-5-desethyl-2,3-secoandrosta-8-ene-7-one ,  (1S)-1-Acetoxy-2-methoxy-6-(allyloxy)-11α-(tert-butyldimethylsiloxy)-17,17-[ethylenebis(oxy)]-5-desethyl-2,3-secoandrosta-5,8-diene-7-one ,  (1S)-1-Acetoxy-1-(methoxymethyl)-6,7-[methoxymethylenebis(oxy)]-11α-(tert-butyldimethylsiloxy)-17,17-[ethylenebis(oxy)]-1,2-seco-5α-androsta-2,8-diene ,  (1S)-1-Acetoxy-2-methoxy-6,7-[methoxymethylenebis(oxy)]-11α-(tert-butyldimethylsiloxy)-17,17-[ethylenebis(oxy)]-3-oxo-2,3-seco-5α-androsta-8-ene ,  1α-(Methoxymethyl)-4-[(Z)-hydroxymethylene]-11α-(tert-butyldimethylsiloxy)-6,7-[methoxymethylenebis(oxy)]-17,17-[ethylenebis(oxy)]-2-oxa-5α-androsta-8-ene-3-one ,  1α-(Methoxymethyl)-4-(methoxymethylene)-11α-(tert-butyldimethylsiloxy)-6,7-dihydroxy-17,17-[ethylenebis(oxy)]-2-oxa-5α-androsta-8-ene-3-one ,  1α-(Methoxymethyl)-4-(methoxymethylene)-11α-(tert-butyldimethylsiloxy)-6α-hydroxy-17,17-[ethylenebis(oxy)]-2-oxa-5α-androsta-8-ene-3,7-dione ,  1α-(Methoxymethyl)-4-(methoxymethylene)-11α-(tert-butyldimethylsiloxy)-6-hydroxy-17,17-[ethylenebis(oxy)]-2-oxaandrosta-5,8-diene-3,7-dione ,  (1S)-1,6bβ,7,8,9a,10,11,11b-Octahydro-11β-(tert-butyldimethylsiloxy)-1-(methoxymethyl)-9aα,11bα-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione

Terms in the title (2)： ウォルトマンニン ,  全合成