Art

J-GLOBAL ID：200902166832528355   Reference number：97A0133365

New Antitumor Substances, FR901463, FR901464 and FR901465. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities.

新抗腫よう物質,FR901463,FR901464とFR901465 1 分類,発酵,単離,物理化学的性質と生物活性

Author (6)： NAKAJIMA H (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  SATO B (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  FUJITA T (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  TAKASE S (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  TERANO H (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN) ,  OKUHARA M (Fujisawa Pharmaceutical Co., Ltd., Ibaraki, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 49  Issue： 12  Page： 1196-1203  Publication year： Dec. 1996 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Pseudomonas ,...
Semi thesaurus term： FR-901463 ,...

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JST classification (1)： Antibiotic fermentation  (GX03000S)

Substance index (3)： WB-2663A ,  FR-901464 ,  WB-2663C

Reference (15)：

• 1) LOWE, S. W. & H. E. RULEY: Stabilization of the p53 tumor suppressor is induced by adeno virus 5 El A and accompanies apoptosis. Genes & Dev. 7: 535-545, 1993
• 2) WAGNER, A. J.; J. M. KOKONTIS & N. HAY: Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21^waf1/cip1 Genes & Dev 8. 2817-2830, 1996
• 3) Wu, X. & A. J. LEVINE: p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. U.SA. 91: 3602-3606, 1994
• 4) TAN, T. M. C. & R. C. Y. TING: In vitro and in vivo inhibition of human papillomavirus type 16 E6 and E7 genes. Cancer Res. 55: 4599-4605, 1995
• 5) EASTHAM, J. A.; S. J. HALL, I. SEHGAL, J. WANG, T. L. TIMME, G. YANG, L. CONNELL-CROWLEY, S. J. ELLEDGE, W. ZHANG, J. W. HARPER & T. C. THOMPSON: In vitro gene therapy with p53 or p21 adenovirus for prostate cancer. Cancer Res. 55: 5151-5155, 1995

Terms in the title (6)： 抗腫よう物質 ,  分類 ,  発酵 ,  単離 ,  物理化学的性質 ,  生物活性