Art

J-GLOBAL ID：200902166859498245   Reference number：96A0771315

Potent Thrombin Inhibitors That Probe the S₁′ Subsite: Tripeptide Transition State Analogues Based on a Heterocycle-Activated Carbonyl Group.

S₁′サブサイトを探る有力なトロンビン抑制薬 ヘテロ環活性化カルボニル基に基づくトリペプチド遷移状態同族体

Author (9)： COSTANZO M J (R.W. Johnson Pharmaceutical Res. Inst., Pennsylvania) ,  HECKER L R (R.W. Johnson Pharmaceutical Res. Inst., Pennsylvania) ,  SCHOTT M R (R.W. Johnson Pharmaceutical Res. Inst., Pennsylvania) ,  YABUT S C (R.W. Johnson Pharmaceutical Res. Inst., Pennsylvania) ,  ZHANG H-C (R.W. Johnson Pharmaceutical Res. Inst., Pennsylvania) ,  KAUFFMAN J A (R.W. Johnson Pharmaceutical Res. Inst., Pennsylvania) ,  LEWIS J M (R.W. Johnson Pharmaceutical Res. Inst., Pennsylvania) ,  KRISHNAN R (Michigan State Univ., Michigan) ,  TULINSKY A (Michigan State Univ., Michigan)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 39  Issue： 16  Page： 3039-3043  Publication year： Aug. 02, 1996 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： antithrombin ,...
Semi thesaurus term： RWJ-50353 ,...

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JST classification (2)： Basic research of drugs acting on blood and body fluid  (GW14010M) ,  Peptides  (CF10080G)

Substance index (13)： Cyclotheonamide A ,  Efegatran ,  Argatroban ,  RWJ-50353 ,  2-[N^α-[1-(N-Methyl-D-phenylalanyl)-L-prolyl]-L-arginyl]thiazole ,  2-[N^α-[1-(N-Methyl-D-phenylalanyl)-L-prolyl]-L-arginyl]benzo[b]thiophene ,  2-[N^α-[1-(N-Methyl-D-phenylalanyl)-L-prolyl]-L-arginyl]benzoxazole ,  2-[N^α-[1-(N-Methyl-D-phenylalanyl)-L-prolyl]-L-arginyl]-4,5,6,7-tetrahydrobenzothiazole ,  2-[N^α-[1-(N-Methyl-D-phenylalanyl)-L-prolyl]-L-arginyl]-1H-benzimidazole ,  2-[N^α-[1-(N-Methyl-D-phenylalanyl)-L-prolyl]-L-arginyl]-1-methyl-1H-benzimidazole ,  2-[N^α-[1-(N-Methyl-D-phenylalanyl)-L-prolyl]-L-arginyl]-1-methyl-1H-imidazole ,  2-[N^α-[1-(N-Methyl-D-phenylalanyl)-L-prolyl]-L-arginyl]quinazolin-4(3H)-one ,  2-[N^α-[1-(N-Methyl-D-phenylalanyl)-L-prolyl]-L-arginyl]pyridine

Terms in the title (8)： サブ ,  トロンビン ,  ヘテロ環 ,  活性化 ,  カルボニル基 ,  トリペプチド ,  遷移状態 ,  同族体