Art

J-GLOBAL ID：200902168222925207   Reference number：94A0263262

Mode of analgesic action of phenolic dental medicaments through substance P release.

フェノール性歯髄鎮痛薬のサブスタンスPを中心とした作用機序

Author (4)： SHIBATA MANABU (福岡歯大) ,  OKUBO TSUYAKO (福岡歯大) ,  TSURUDA KATSUHIKO (福岡歯大) ,  TAKAHASHI HIROSHI (福岡歯大)
Material： 歯科基礎医学会雑誌  (Japanese Journal of Oral Biology)
Volume： 36  Issue： 1  Page： 49-59  Publication year： Feb. 1994 
JST Material Number： Y0018A  ISSN： 0385-0137  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： eugenol ,...

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JST classification (3)： Basic research of anti-inflammatory drugs  (GW15010T) ,  Bioactive peptides  (EB08100U) ,  Basic dentistry(= odontology)  (GT01020O)

Substance index (5)： Capsaicin ,  Guaiacol ,  Thymol ,  Eugenol ,  Spantide

Reference (44)：

• 1) Jancsó, N., Jancsó-Gábor, A. and Szolcsányi, J.: Direct evidence for neurogenic inflammation and its prevention by denervation and by preteatment with capsaicin. Br. J. Pharmacol. Chemother. 31: 138-151, 1967.
• 2) Lembeck, F. and Holzer, P.: Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. Naunyn -Schmiedeberg's Arch. Pharmacol. 310: 175-183, 1979.
• 3) Lembeck, F., Donnerer, J. and Barthó, L.: Inhibition of neurogenic vasodilatation and plasma extravasation by substance P antagonists, somatostatin and [D-Met2, Pro5] enkephalinamide. Eur. J. Pharmacol. 85: 171-176, 1982.
• 4) Belvisi, M. G., Rogers, D. F. and Barnes, P. J.: Neurogenic plasma extravasation: inhibition by morphine in guinea pig airways in vivo. J. Appl. Physol. 66: 268-272, 1989.
• 5) Barnes, P. J., Belvisi, M. G. and Rogers, D. F.: Modulation of neurogenic inflammation: novel approaches to inflammatory disease. Trends Pharmacol. Sci. 11: 185-189, 1990.

Terms in the title (5)： フェノール ,  歯髄 ,  鎮痛薬 ,  サブスタンスP ,  作用機序