Art

J-GLOBAL ID：200902168676685499   Reference number：02A0182292

Isolation of a Novel Cyclic Hexadepsipeptide Pipalamycin from Streptomyces as an Apoptosis-inducing Agent.

Streptomycesから単離したアポトーシス誘発薬としての新規環状ヘキサデプシペプチドのピパラマイシン

Author (6)： UCHIHATA Y (Keio Univ.,Yokohama,JPN) ,  ANDO N (Keio Univ.,Yokohama,JPN) ,  IKEDA Y (Inst. Microbial Chemistry, Tokyo, JPN) ,  KONDO S (Inst. Microbial Chemistry, Tokyo, JPN) ,  HAMADA M (Inst. Microbial Chemistry, Tokyo, JPN) ,  UMEZAWA K (Keio Univ.,Yokohama,JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 55  Issue： 1  Page： 1-5  Publication year： Jan. 25, 2002 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antineoplastic antibiotics ,...
Semi thesaurus term： Streptomyces ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=02A0182292&from=J-GLOBAL&jstjournalNo=G0489A") }}

JST classification (1)： Antibiotics in general  (GX01000E)

Substance index (1)： IC-101

Reference (7)：

• 1) CHEN, W. H.; J. S. HOROSZEWICZ, S. S. LEONG, T. SHIMANO, R. PENETRANTE, W. H. SANDERS, R. BERJIAN, H. O. DOUGLASS, E. W. MARTIN & M. T. CHU: Human pancreatic adenocarcinome: In vitro and in vivo morphology of a new tumor line established from ascites. In Vitro 18: 24-34, 1981
• 2) UMEZAWA, K.; K. NAKAZAWA, Y. IKEDA, H. NAGANAWA & S. KONDO: Polyoxypeptins A and B produced by Streptomyces: Apoptosis-inducing cyclic depsipeptides containing the novel amino acid (2S,3R) 3-hydroxy-3-methylproline. J. Org. Chem. 64: 3034-3038, 1999
• 3) UMEZAWA, K.; Y. IKEDA, Y. UCHIHATA, H. NAGANAWA & S. KONDO: Chloptosin, an apoptosis-inducing dimeric cyclohexapeptide produced by Streptomyces. J. Org. Chem. 65: 459-463, 2000
• 4) UMEZAWA, K.; Y. IKEDA, O. KAWASE, H. NAGANAWA & S. KONDO: Biosynthesis of polyoxypeptin A: novel amino acid 3-hydroxy-3-methylproline derived from isoleucine. J. Chem. Soc., Perkin Trans. 1 2001: 1550-1553
• 5) UENO, M.; M. AMEMIYA, T. SOMENO, T. MASUDA, H. IINUMA, H. NAGANAWA, M. HAMADA, M. ISHIZUKA & T. TAKEUCHI: IC101, extracellular matrix antagonist produced by Streptomyces sp. MJ202-72F3. Production, isolation, structure determination and biological activity. J. Antibiotics 46: 1658-1665, 1993

Terms in the title (5)： Streptomyces ,  単離 ,  アポトーシス誘発 ,  環状 ,  デプシペプチド