Art

J-GLOBAL ID：200902168689610439   Reference number：00A0114099

5-Hydroxy-4-oxo-L-norvaline Depletes Intracellular Glutathione: a New Modulator of Drug Resistance.

5-ヒドロキシ-4-オキソ-L-ノルバリンは細胞内グルタチオン濃度を減少させる 新しい薬剤耐性解除剤

Author (6)： TAGASHIRA M (Asahi Breweries Ltd., Ibaraki, JPN) ,  NOZATO N (Asahi Breweries Ltd., Ibaraki, JPN) ,  ISONISHI S (Jikei Univ. School of Medicine, Tokyo, JPN) ,  OKAMOTO A (Jikei Univ. School of Medicine, Tokyo, JPN) ,  OCHIAI K (Jikei Univ. School of Medicine, Tokyo, JPN) ,  OHTAKE Y (Asahi Breweries Ltd., Ibaraki, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 63  Issue： 11  Page： 1953-1958  Publication year： Nov. 23, 1999 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Actinomyces ,...

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JST classification (2)： Microorganism biochemistry  (EG03020N) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (3)： (+)-2-Aminovaleric acid ,  Glutathione ,  HON

Reference (28)：

• 1) Redwood, W. R. and Colvin, M., Transport of melphalan by sensitive and resistant L1210 cells. Cancer Res., 40, 1144-1149 (1980).
• 2) Wang, A. L. and Tew, K. D., Increased glutathione S-transferase activity in a cell line with acquired resistance to nitrogen mustards. Cancer Treat. Rep., 69, 677-682 (1985).
• 3) Pegg, A. E., Mammalian O⁶-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res., 50, 6119-6129 (1990).
• 4) Godwin, A. K., Meister, A., O’Dwyer, P. J., Huang, C. S., Hamilton, T. C., and Anderson, A. E., High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Proc. Natl. Acad. Sci. USA., 89, 3070-3074 (1992).
• 5) Goto, S., Yoshida, K., Morikawa, T., Urata, Y., Suzuki, K., and Kondo T., Augmentation of transport for cisplatin-glutathione adduct in cisplatin-resistant cancer cells. Cancer Res., 55, 4297-4301 (1995).

Terms in the title (3)： L-ノルバリン ,  グルタチオン ,  薬剤耐性