Art

J-GLOBAL ID：200902168696534071   Reference number：99A0723225

Pyrrolidines bearing a quaternary α-stereogenic center. Part 1: Synthesis of analogs of ABT-418, a powerful nicotinic agonist.

四級α-不斉中心を持つピロリジン類 1 強力なニコチン性アゴニストであるABT-418の類似体の合成

Author (3)： GIARD T (Univ. Rouen, Mont-Saint-Aignan, FRA) ,  LASNE M-C (ISMRA, Caen, FRA) ,  PLAQUEVENT J-C (Univ. Rouen, Mont-Saint-Aignan, FRA)
Material： Tetrahedron Letters  (Tetrahedron Lett)
Volume： 40  Issue： 30  Page： 5495-5497  Publication year： Jul. 23, 1999 
JST Material Number： E0366A  ISSN： 0040-4039  Document type： Article
Article type： 短報  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *nitrogen heterocyclic compound ,...

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JST classification (2)： Oxazoles,isoxazoles  (CF07080Y) ,  Synthesis of drugs  (GV01030F)

Substance index (10)： ABT-418 ,  (±)-ABT-418 ,  3-(3-Methylisoxazole-5-yl)pyridine ,  rac-1-Methyl-2-(3-methylisoxazole-5-yl)pyrrolidine-2α^*-carbaldehyde ,  rac-N,1-Dimethyl-2-(3-methylisoxazole-5-yl)pyrrolidine-2α^*-methanimine ,  rac-N-Phenyl-1-methyl-2-(3-methylisoxazole-5-yl)pyrrolidine-2α^*-methanimine ,  rac-N-Benzyl-1-methyl-2-(3-methylisoxazole-5-yl)pyrrolidine-2α^*-methanamine ,  rac-1-Methyl-2-(3-methylisoxazole-5-yl)pyrrolidine-2α^*-methanol ,  rac-Acetic acid [1-methyl-2-(3-methylisoxazole-5-yl)pyrrolidine-2α^*-ylmethyl] ester ,  rac-Benzoic acid [1-methyl-2-(3-methylisoxazole-5-yl)pyrrolidine-2α^*-ylmethyl] ester

Terms in the title (6)： 不斉中心 ,  ピロリジン類 ,  ニコチン ,  アゴニスト ,  ABT-418 ,  類似体