Art

J-GLOBAL ID：200902169108088911   Reference number：01A0921815

Altered Topoisomerase IIα and Multidrug Resistance-associated Protein Levels during Drug Selection. Adaptations to Increasing Drug Pressure.

薬剤選択時にみられるトポイソメラーぜIIαと多剤耐性関連蛋白質レベルの変化 増大する薬剤プレッシャーに対する適応

Author (4)： MATSUMOTO Y (Kagawa Medical Univ., Kagawa) ,  TAKANO H (NIH, MD, USA) ,  NAGAO S (Kagawa Medical Univ., Kagawa) ,  FOJO T (NIH, MD, USA)
Material： Japanese Journal of Cancer Research  (Proceedings. Annual Meeting of the Japanese Cancer Association)
Volume： 92  Issue： 9  Page： 968-974  Publication year： Sep. 30, 2001 
JST Material Number： F0633A  ISSN： 0910-5050  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *multiple drug resistance ,...
Semi thesaurus term： MRP

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JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： Etoposide ,  Amsacrine

Reference (19)：

• TEWEY, K. M. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science. 1984, 226, 466-468
• WANG, J. C. DNA topoisomerase. Annu. Rev. Biochem. 1985, 54, 655-697
• DRLICA, K. Inhibitors of DNA topoisomerases. Biochemistry. 1988, 27, 2253-2259
• LIU, L. F. DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem. 1989, 58, 351-375
• BERGER, J. C. Structure and mechanism of DNA topoisomerase II. Nature. 1996, 379, 225-232

Terms in the title (5)： 薬剤選択 ,  多剤耐性関連蛋白質 ,  薬剤 ,  プレッシャー ,  適応