Art

J-GLOBAL ID：200902169208219789   Reference number：02A0329418

Role of Rho-Associated Protein Kinase and Histamine in Lysophosphatidic Acid-Induced Airway Hyperresponsiveness in Guinea Pigs.

モルモットのリゾホスファチジン酸誘発気道反応亢進におけるRho結合蛋白質キナーゼとヒスタミンの役割

Author (6)： HASHIMOTO T (Showa Univ., Tokyo, JPN) ,  NAKANO Y (Showa Univ., Tokyo, JPN) ,  YAMASHITA M (Showa Univ., Tokyo, JPN) ,  FANG Y-I (Showa Univ., Tokyo, JPN) ,  OHATA H (Showa Univ., Tokyo, JPN) ,  MOMOSE K (Showa Univ., Tokyo, JPN)
Material： Japanese Journal of Pharmacology  (Jpn J Pharmacol)
Volume： 88  Issue： 3  Page： 256-261  Publication year： Mar. 01, 2002 
JST Material Number： G0813A  ISSN： 0021-5198  CODEN： JJPAA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： GTP binding protein ,...
Semi thesaurus term： Rho結合蛋白質キナーゼ ,...

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JST classification (3)： Basic medicine on respiratory system  (GI01020H) ,  Enzyme physiology  (EJ02020P) ,  Biological function  (EB02020R)

Substance index (6)： Histamine ,  Mepyramine ,  Ketotifen ,  Acetylcholine ,  Y-27632 ,  Aspirin

Reference (26)：

• 1 Chung KF, Aizawa H, Leikauf GD, Ueki IF, Evans TW and Nadel JA: Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation. J Pharmacol Exp Ther 236, 580 – 584 (1985)
• 2 Saito M, Fujimura M, Sakamoto S, Miyake Y, Shintani H and Yasui M: Involvement of arachidonate cyclooxygenase products in bronchial hyperresponsiveness induced by subthreshold concentration of aerosolized thromboxane A₂ analogue (STA₂) in guinea pigs. Allergy 47, 181 – 184 (1992)
• 3 Jacques CAJ, Spur BW, Johnson M and Lee TH: The mechanism of LTE₄-induced histamine hyperresponsiveness in guinea-pig tracheal and human bronchial smooth muscle, in vitro. Br J Pharmacol 104, 859 – 866 (1991)
• 4 Omini C, Brunelli G, Hernandez A and Daffonchio L: Bradykinin and substance P potentiate acetylcholine-induced bronchospasm in guinea-pig. Eur J Pharmacol 163, 195 – 197 (1989)
• 5 Hashimoto T, Nakano Y, Ohata H and Momose K: Lysophosphatidic acid enhances airway response to acetylcholine in guinea pigs. Life Sci 70, 199 – 205 (2001)

Terms in the title (8)： モルモット ,  リゾホスファチジン酸 ,  誘発 ,  気道 ,  亢進 ,  蛋白質キナーゼ ,  ヒスタミン ,  役割