Art

J-GLOBAL ID：200902169691546680   Reference number：97A0548516

Cardioprotective Effect of K-7259, a Novel Dilazep Derivative, against Ischemia-Reperfusion Damage in Isolated, Working Rat Hearts.

単離,作動ラット心における虚血再潅流障害に対する新規ジラゼプ誘導体K-7259の心保護効果

Author (6)： HOQUE A N E (Asahikawa Medical Coll., Asahikawa, JPN) ,  HOQUE N (Asahikawa Medical Coll., Asahikawa, JPN) ,  HARA A (Asahikawa Medical Coll., Asahikawa, JPN) ,  HASHIZUME H (Asahikawa Medical Coll., Asahikawa, JPN) ,  ICHIHARA K (Hokkaido Coll. Pharmacy, Otaru, JPN) ,  ABIKO Y (Asahikawa Medical Coll., Asahikawa, JPN)
Material： Japanese Journal of Pharmacology  (Jpn J Pharmacol)
Volume： 73  Issue： 4  Page： 365-369  Publication year： Apr. 1997 
JST Material Number： G0813A  ISSN： 0021-5198  CODEN： JJPAA  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： coronary vasodilator ,...
Semi thesaurus term： K-7259 ,...

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JST classification (1)： Basic research of cardioactive drugs  (GW07020N)

Substance index (1)： K-7259

Reference (15)：

• 1 Sugiyama S, Kondo T, Ajioka M, Hattori M, Nagai S and Ozawa T: The effects of dilazep on reperfusion arrhythmias. Arzneimittelforschung 35, 1802-1804 (1985)
• 2 Hoque ANE, Hoque N, Hashizume H and Abiko Y: A study of dilazep: I. Mechanism of anti-ischemic action of dilazep is not coronary vasodilation but decreased cardiac mechanical function in the isolated, working rat heart. Jpn J Pharmacol 67, 225-232 (1995)
• 3 Mustafa SJ: Effects of coronary vasodilator drugs on the uptake and release of adenosine in cardiac cells. Biochem Pharmacol 28, 2617-2624 (1979)
• 4 Meghji P, Middleton K, Hassall CJS, Phillips MI and Newby AC: Evidence for extracellular deamination of adenosine in the rat heart. Int J Biochem 20, 1335-1341 (1988)
• 5 Hara A, Akahira M and Abiko Y: Effect of K-7259, a novel derivative of dilazep, on cardiovascular actions of adenosine: Comparison with dilazep. Arch Int Pharmacodyn Ther 330, 66-75 (1995)

Terms in the title (8)： 単離 ,  ラット ,  虚血再潅流障害 ,  ジラゼプ ,  誘導体 ,  K-7259 ,  心 ,  保護効果