Art

J-GLOBAL ID：200902169845619472   Reference number：02A0761714

Novel [D-Arg²]dermorphin(1-4) Analogs with μ-Opioid Receptor Antagonist Activity.

μ-オピオイド受容体きっ抗薬活性を持つ新規な[D-Arg²]デルモルフィン(1-4)類似体

Author (3)： AMBO A (Tohoku Pharmaceutical Univ., Sendai, JPN) ,  TERASHIMA T (Tohoku Pharmaceutical Univ., Sendai, JPN) ,  SASAKI Y (Tohoku Pharmaceutical Univ., Sendai, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 50  Issue： 10  Page： 1401-1403  Publication year： Oct. 01, 2002 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： opioid peptide ,...

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JST classification (1)： Peptides  (CF10080G)

Substance index (10)： L-Tyr-D-Arg-N-Benzyl-Gly-βAla-NH₂ ,  L-Tyr-N-(3-Guanidinopropyl)-Gly-L-Phe-βAla-NH₂ ,  N-(4-Hydroxybenzyl)-Gly-D-Arg-L-Phe-βAla-NH₂ ,  N-(4-Hydroxybenzyl)-4-hydroxy-L-phenyl Gly-D-Arg-L-Phe-βAla-NH₂ ,  N,N-Bis(4-hydroxybenzyl)-Gly-D-Arg-L-Phe-βAla-NH₂ ,  N,N-Bis(4-hydroxybenzyl)-Gly-D-Arg-L-Phe-NH₂ ,  N,N-Bis(4-hydroxybenzyl)-Gly-D-Arg-NH₂ ,  N,N-Dibenzyl-Gly-D-Arg-L-Phe-βAla-NH₂ ,  N,N-Bis(4-hydroxybenzyl)-Gly-L-Arg-L-Phe-βAla-NH₂ ,  N^α,N^α-Bis(4-hydroxybenzyl)-D-Arg-L-Phe-βAla-NH₂

Reference (22)：

• 1) Amino acids and peptides are of L-configuration unless otherwise noted. Amino acids and peptides used are those recommended by the IUPAC-IUB Commission on Biochemical Nomenclature in Eur. J. Biochem., 139, 9 (1984). Other abbreviations used are: YRFB=Tyr-D-Arg-Phe-βAla-NH₂, DMF=dimethylformamide, DICDI=diisopropylcarbodiimide, HOBt=1-hydroxybenzotriazole, DIPEA=diisopropylethylamine, DAMGO=[D-Ala², MePhe⁴, Gly-ol⁵]enkephalin, DPDPE=[D-Pen², D-Pen⁵]enkephalin, Tos=tosyl, Fmoc=N-9-fluorenylmethyloxycarbonyl, PyBOP=benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate, MBHA resin=methoxybenzohydrylamine resin, GPI=guinea pig ileum.
• 2) Dhawan B. N., Cesselin F., Raghubir R., Reisine T., Bradley P. B., Portoghese P. S., Hamon M., Pharmacol. Rev., 48, 567—592 (1996).
• 3) Sasaki Y., Ambo A., Suzuki K., Chem. Pharm. Bull., 39, 2316—2318 (1991).
• 4) Simon R. J., Kania R. S., Zuckermann R. N., Huebner V. D., Jewell D. A., Banbille S., Ng S., Wang L., Rosenberg S., Marlowe C. K., Spellmeyer D. C., Tan R., Frankel A. D., Santi D. V., Cohen F. E., Bartlett P. A., Proc. Natl. Acad. Sci. U.S.A., 89, 9367—9371 (1992).
• 5) Suh J. T., Skiles J. W., Williams B. E., Youssefyeh R. D., Jones H., Loev B., Neiss E. S., Schwab A., Mann W. S., Khandwala A., Wolf P. S., Weinryb I., J. Med. Chem., 28, 57—66 (1985).

Terms in the title (5)： オピオイド受容体 ,  きっ抗薬 ,  活性 ,  デルモルフィン ,  類似体