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J-GLOBAL ID：200902169915344107   Reference number：02A0123978

Tyropeptins A and B, New Proteasome Inhibitors Produced by Kitasatospora sp. MK993-dF2. I. Taxonomy, Isolation, Physico-chemical Properties and Biological Activities.

チロペプチンAとB,Kitasatospora sp.MK993-dF2が生産する新規プロテアソーム抑制剤 I 分類,単離,物理化学的性質と生物活性

Author (8)： MOMOSE I (Inst. Microbial Chemistry, Tokyo, JPN) ,  SEKIZAWA R (Inst. Microbial Chemistry, Tokyo, JPN) ,  HASHIZUME H (Inst. Microbial Chemistry, Tokyo, JPN) ,  KINOSHITA N (Inst. Microbial Chemistry, Tokyo, JPN) ,  HOMMA Y (Inst. Microbial Chemistry, Tokyo, JPN) ,  HAMADA M (Inst. Microbial Chemistry, Tokyo, JPN) ,  IINUMA H (Inst. Microbial Chemistry, Tokyo, JPN) ,  TAKEUCHI T (Inst. Microbial Chemistry, Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 54  Issue： 12  Page： 997-1003  Publication year： Dec. 25, 2001 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antibiotic producing microorganism ,...
Semi thesaurus term： Kitasatospora sp. MK993-dF2

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JST classification (2)： Antibiotic fermentation  (GX03000S) ,  Basic research of antitumor(=antineoplastic)antibiotics  (GX05040Y)

Substance index (2)： Tyropeptin A ,  Tyropeptin B

Reference (24)：

• 1) COUX, O.; K. TANAKA & A. L. GOLDBERG: Structure and function of the 20S and 26S proteasome. Annu. Rev. Biochem. 65: 801-847, 1996
• 2) HERSHKO, A. & A. CIECHANOVER: The ubiquitin system for protein degradation. Annu. Rev. Biochem. 61: 761-807, 1992
• 3) VORGE, D.; P. ZWICKL & W. BAUMEISTER: The 26S proteasome: A molecular machine designed for controlled proteolysis. Annu. Rev. Biochem. 68: 1015-1068, 1999
• 4) HERSHKO, A. & A. CIECHANOVER: The ubiquitin system. Annu. Rev. Biochem. 67: 425-479, 1998
• 5) MAKI C. G. & P. M. HOWI.EY: Ubiquitinafion of p53 and p21 is differentially affected by ionizing and UV radiation. Mol. Cell Biol. 17: 355-363, 1997

Terms in the title (7)： Kitasatospora ,  プロテアソーム ,  抑制剤 ,  分類 ,  単離 ,  物理化学的性質 ,  生物活性