Art

J-GLOBAL ID：200902170415100501   Reference number：98A0902275

New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 3. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory ans Analgesic Agents: Variations at the 5 Position.

新規シクロオキシゲナーゼ-2/5-リポキシゲナーゼ阻害薬 3 消化器に安全な抗炎症鎮痛薬としての7-tert-ブチル-2,3-ジヒドロ-3,3-ジメチルベンゾフラン誘導体 5位の置換基変換

Author (9)： JANUSZ J M (Procter & Gamble Pharmaceuticals, Ohio) ,  YOUNG P A (Procter & Gamble Pharmaceuticals, Ohio) ,  RIDGEWAY J M (Procter & Gamble Pharmaceuticals, Ohio) ,  SCHERZ M W (Procter & Gamble Pharmaceuticals, Ohio) ,  ENZWEILER K (Procter & Gamble Pharmaceuticals, Ohio) ,  WU L I (Procter & Gamble Pharmaceuticals, Ohio) ,  GAN L (Procter & Gamble Pharmaceuticals, Ohio) ,  CHEN J (Procter & Gamble Pharmaceuticals, Ohio) ,  DOBSON R L M (Procter & Gamble Pharmaceuticals, Ohio)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 41  Issue： 18  Page： 3515-3529  Publication year： Aug. 27, 1998 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *antiphlogistic ,...

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JST classification (2)： Basic research of anti-inflammatory drugs  (GW15010T) ,  Condensed derivatives of furan  (CF07073M)

Substance index (30)： Tebufelone ,  Naproxen ,  3,3-Dimethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxylic acid ,  3,3-Dimethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxylic acid methyl ester ,  3,3-Dimethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxamide ,  N-Butyl-3,3-dimethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxamide ,  N-Pentyl-3,3-dimethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxamide ,  N-Isopropyl-3,3-dimethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxamide ,  N-Cyclopropyl-3,3-dimethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxamide ,  N-(Cyclopropylmethyl)-3,3-dimethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxamide ,  N-(2,3-Dihydroxypropyl)-3,3-dimethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxamide ,  N-[2-(Dimethylamino)ethyl]-3,3-dimethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxamide ,  N-(2-Thiazolyl)-3,3-dimethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxamide ,  N-(2-Thiazoline-2-yl)-3,3-dimethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxamide ,  N,N,3,3-Tetramethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxamide ,  3,3-Dimethyl-5-(piperidinocarbonyl)-7-tert-butyl-2,3-dihydrobenzofuran ,  3,3-Dimethyl-5-(thiomorpholinocarbonyl)-7-tert-butyl-2,3-dihydrobenzofuran ,  N¹,N¹,3,3-Tetramethyl-7-tert-butyl-2,3-dihydro-5-benzofurancarboxamidine ,  3,3-Dimethyl-5-[pyrrolizino(imino)methyl]-7-tert-butyl-2,3-dihydrobenzofuran ,  N-[(3,3-Dimethyl-7-tert-butyl-2,3-dihydrobenzofuran)-5-yl]acetamide ,  3,3-Dimethyl-5-(2-thienyl)-7-tert-butyl-2,3-dihydrobenzofuran ,  3,3-Dimethyl-5-(4-oxazolyl)-7-tert-butyl-2,3-dihydrobenzofuran ,  3,3-Dimethyl-5-(4-thiazolyl)-7-tert-butyl-2,3-dihydrobenzofuran ,  3,3-Dimethyl-5-(5-methyl-1,2,4-oxadiazole-3-yl)-7-tert-butyl-2,3-dihydrobenzofuran ,  3,3-Dimethyl-5-(2-amino-4-thiazolyl)-7-tert-butyl-2,3-dihydrobenzofuran ,  3,3-Dimethyl-5-(2-furanylcarbonyl)-7-tert-butyl-2,3-dihydrobenzofuran ,  3,3-Dimethyl-5-(3-furanylcarbonyl)-7-tert-butyl-2,3-dihydrobenzofuran ,  3,3-Dimethyl-5-(2-thienylcarbonyl)-7-tert-butyl-2,3-dihydrobenzofuran ,  3,3-Dimethyl-5-(3-thienylcarbonyl)-7-tert-butyl-2,3-dihydrobenzofuran ,  3,3-Dimethyl-5-[(1-methyl-1H-pyrrole-2-yl)carbonyl]-7-tert-butyl-2,3-dihydrobenzofuran

Terms in the title (10)： シクロオキシゲナーゼ-2 ,  5-リポキシゲナーゼ ,  阻害薬 ,  消化器 ,  抗炎症 ,  鎮痛薬 ,  TERT ,  ジメチル ,  ベンゾフラン誘導体 ,  置換基