Art

J-GLOBAL ID：200902171023306990   Reference number：96A0253192

Optically Active Antifungal Azoles. VI. Synthesis and Antifungal Activity of N-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-N′-(4-substituted phenyl)-3(2H,4H)-1,2,4-triazolones and 5(1H,4H)-tetrazolones.

光学活性な抗真菌薬アゾール VI N-[(1R,2R)-2-(2,4-ジフルオロフェニル)-2-ヒドロキシ-1-メチル-3-(1H-1,2,4-トリアゾール-1-イル)プロピル]-N′-(4-置換フェニル)-3(2H,4H)-1,2,4-トリアゾロン及び5(1H,4H)-テトラゾロンの合成と抗真菌作用

Author (7)： KITAZAKI T (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  TAMURA N (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  TASAKA A (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  MATSUSHITA Y (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  HAYASHI R (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  OKONOGI K (Takeda Chemical Ind. Ltd., Osaka, JPN) ,  ITOH K (Takeda Chemical Ind. Ltd., Osaka, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 44  Issue： 2  Page： 314-327  Publication year： Feb. 1996 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： antifungal drug ,...
Semi thesaurus term： Candida albicans ,...

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JST classification (2)： Basic research of antifungal drugs  (GW17060K) ,  Triazoles  (CF07084O)

Substance index (19)： 2-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-4-(4-fluorophenyl)-2H-1,2,4-triazol-3(4H)-one ,  2-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-4-[4-(trifluoromethyl)phenyl]-2H-1,2,4-triazol-3(4H)-one ,  2-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,4-triazol-3(4H)-one ,  2-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-4-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-2H-1,2,4-triazol-3(4H)-one ,  2-[(1R,2R)-1-Methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-4-[4-(2,2,2-trifluoroethoxy)phenyl]-2H-1,2,4-triazol-3(4H)-one ,  TAK-187 ,  2-(4-Fluorophenyl)-4-[(1R,2R)-1-methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-2H-1,2,4-triazol-3(4H)-one ,  2-[4-(Trifluoromethyl)phenyl]-4-[(1R,2R)-1-methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-2H-1,2,4-triazol-3(4H)-one ,  2-[4-(Trifluoromethoxy)phenyl]-4-[(1R,2R)-1-methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-2H-1,2,4-triazol-3(4H)-one ,  2-[4-(1,1,2,2-Tetrafluoroethoxy)phenyl]-4-[(1R,2R)-1-methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-2H-1,2,4-triazol-3(4H)-one ,  2-[4-(2,2,2-Trifluoroethoxy)phenyl]-4-[(1R,2R)-1-methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-2H-1,2,4-triazol-3(4H)-one ,  2-[4-(2,2,3,3-Tetrafluoropropoxy)phenyl]-4-[(1R,2R)-1-methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-2H-1,2,4-triazol-3(4H)-one ,  1-(4-Fluorophenyl)-4-[(1R,2R)-1-methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-1H-tetrazol-5(4H)-one ,  1-[4-(Trifluoromethyl)phenyl]-4-[(1R,2R)-1-methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-1H-tetrazol-5(4H)-one ,  1-[4-(Trifluoromethoxy)phenyl]-4-[(1R,2R)-1-methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-1H-tetrazol-5(4H)-one ,  1-[4-(1,1,2,2-Tetrafluoroethoxy)phenyl]-4-[(1R,2R)-1-methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-1H-tetrazol-5(4H)-one ,  1-[4-(2,2,2-Trifluoroethoxy)phenyl]-4-[(1R,2R)-1-methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-1H-tetrazol-5(4H)-one ,  1-[4-(2,2,3,3-Tetrafluoropropoxy)phenyl]-4-[(1R,2R)-1-methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-1H-tetrazol-5(4H)-one ,  1-[4-(2,2,3,3,3-Pentafluoropropoxy)phenyl]-4-[(1R,2R)-1-methyl-2-hydroxy-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl]-1H-tetrazol-5(4H)-one

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Terms in the title (7)： 光学活性 ,  抗真菌薬 ,  アゾール ,  トリアゾール ,  ピル ,  置換フェニル ,  抗真菌作用