Art

J-GLOBAL ID：200902171304685019   Reference number：95A0733854

5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: A Novel 5-HT_2C/5-HT_2B Receptor Antagonist with improved Affinity, Selectivity, and Oral Activity.

5-メチル-1-(3-ピリジルカルバモイル)-1,2,3,5-テトラヒドロピロロ[2,3-f]インドール 親和力,選択性及び経口投与による活性を改善した新規5-HT_2C/5-HT_2B受容体きっ抗薬

Author (9)： FORBES I T (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  HAM P (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  BOOTH D H (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  MARTIN R T (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  THOMPSON M (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  BAXTER G S (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  BLACKBURN T P (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  GLEN A (SmithKline Beecham Pharmaceuticals, Essex, GBR) ,  WOOD M D (SmithKline Beecham Pharmaceuticals, Essex, GBR)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 38  Issue： 14  Page： 2524-2530  Publication year： Jul. 07, 1995 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： serotonin antagonist ,...
Semi thesaurus term： SB-200646A ,...

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JST classification (2)： Basic research of psychotropic drugs  (GW03100Y) ,  Receptors on cell membrane  (EF04030C)

Substance index (7)： N-(3-Pyridyl)-3-methyl-8,9-dihydro-3H-pyrrolo[3,2-f]quinoline-6(7H)-carboxamide ,  N-(3-Pyridyl)-1-methyl-7,8-dihydro-1H-pyrrolo[2,3-g]quinoline-5(6H)-carboxamide ,  1-[[5-(Trifluoroacetyl)-1,2,3,5-tetrahydrobenzo[1,2-b:4,5-b′]dipyrrol]-1-yl]ethanone ,  1-[[1,2,3,5-Tetrahydrobenzo[1,2-b:4,5-b′]dipyrrol]-1-yl]ethanone ,  1-[[5-Methyl-1,2,3,5-tetrahydrobenzo[1,2-b:4,5-b′]dipyrrol]-1-yl]ethanone ,  SB-206553 ,  N-(3-Pyridyl)-6-methyl-1,6-dihydrobenzo[1,2-b:4,3-b′]dipyrrole-3(2H)-carboxamide

Terms in the title (7)： インドール ,  親和力 ,  選択性 ,  経口投与 ,  活性 ,  5-HT2B受容体 ,  きっ抗薬