Art

J-GLOBAL ID：200902171715553806   Reference number：02A0337243

Expression of P-glycoprotein in rat hepatocarcinogenesis by diethylnitrosamine and the modulation by anticancer drugs.

ジエチルニトロソアミンによるラット肝臓癌生成におけるP-糖蛋白質の発現と抗癌剤による調節

Author (4)： TAKEUCHI Y (Toho Univ. School of Medicine, Tokyo, JPN) ,  SUGIMOTO M (Toho Univ. School of Medicine, Tokyo, JPN) ,  OCHIAI K (Toho Univ. School of Medicine, Tokyo, JPN) ,  ITO K (Toho Univ. School of Medicine, Tokyo, JPN)
Material： Hepatology Research  (Hepatol Res)
Volume： 22  Issue： 2  Page： 107-118  Publication year： Feb. 2002 
JST Material Number： W1284A  ISSN： 1386-6346  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： *dichlorodiammine platinum

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JST classification (2)： Carcinogenic mechanisms and factors  (GE02020C) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： Diethylnitrosamine ,  Epirubicin

Reference (26)：

• JULIANO, RL. A surface glycoprotein in modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta. 1976, 455, 152-162
• RIORDAN, JR. Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability. J Biol Chem. 1979, 254, 12701-12705
• ENDICOTT, JA. The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem. 1989, 58, 137-171
• THIEBAUT, F. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA. 1987, 84, 7735-7738
• GOTTESMAN, MM. The multidrug transporter, a double edged sword. J Biol Chem. 1988, 263, 12163-12166

Terms in the title (7)： ジエチルニトロソアミン ,  ラット ,  肝臓癌 ,  P-糖蛋白質 ,  発現 ,  抗癌剤 ,  調節