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J-GLOBAL ID：200902172526192157   Reference number：00A0106782

Insight into the Molecular Evolution of Two Tropinone Reductases.

二つのトロピノン還元酵素の分子進化についての考察

Author (4)： NAKAJIMA K (Nara Inst. Sci. and Technol., Nara, JPN) ,  OSHITA Y (Nara Inst. Sci. and Technol., Nara, JPN) ,  YAMADA Y (Nara Inst. Sci. and Technol., Nara, JPN) ,  HASHIMOTO T (Nara Inst. Sci. and Technol., Nara, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 63  Issue： 10  Page： 1819-1822  Publication year： Oct. 23, 1999 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： molecular evolution ,...
Semi thesaurus term： *oxidoreductase ,...

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JST classification (2)： Enzyme in general  (EB09010D) ,  Evolution theory in general  (EC03010Q)

Substance index (3)： Tropine ,  Tropinone ,  Pseudotropine

Reference (16)：

• 1) Kutchan, T. M., Alkaloid biosynthesis-The bases for metabolic engineering of medicinal plants. Plant Cell, 7, 1059-1070 (1995).
• 2) Saito, K. and Murakoshi, I., Genes in alkaloid metabolism. In “Alkaloids-Biochemistry, Ecology, and Medicinal Applications,” eds. Roberts, F. M. and Wink, M., Plenum Press, New York, pp. 147-157 (1998).
• 3) Nakajima, K., Hashimoto, T., and Yamada, Y., Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor. Proc. Natl. Acad. Sci. USA, 90, 9591-9595 (1993).
• 4) Jörnvall, H., Persson, B., Krook, M., Atrian, S., Gonzàlez-Duarte, R., Jeffery, J., and Ghosh, D., Short-chain dehydrogenase/reductase (SDR). Biochemistry, 34, 6003-6013 (1995).
• 5) Nakajima, K., Yamashita, A., Akama, H., Nakatsu, T., Kato, H., Hashimoto, T., Oda, J., and Yamada, Y., Crystal structures of two tropinone reductases: Different reaction stereospecificities in the same protein fold. Proc. Natl. Acad. Sci. USA, 95, 4876-4881 (1998).

Terms in the title (3)： トロピノン ,  還元酵素 ,  分子進化