Art

J-GLOBAL ID：200902173387425253   Reference number：00A0225185

Tyrosine Kinase Inhibitors. 16. 6,5,6-Tricyclic Benzothieno[3,2-d]pyrimidines and Pyrimido[5,4-b]- and -[4,5-b]indoles as Potent Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase.

チロシンキナーゼ阻害剤 16 上皮成長因子受容体チロシンキナーゼの強力な阻害剤として6,5,6-三環系ベンゾチエノ[3,2-d]ピリミジン類及びピリミド[5,4-b]-及び[4,5-b]インドール類

Author (6)： SHOWALTER H D H (Parke-Davis Pharmaceutical Res., Michigan) ,  BRIDGES A J (Parke-Davis Pharmaceutical Res., Michigan) ,  ZHOU H (Parke-Davis Pharmaceutical Res., Michigan) ,  SERCEL A D (Parke-Davis Pharmaceutical Res., Michigan) ,  MCMICHAEL A (Parke-Davis Pharmaceutical Res., Michigan) ,  FRY D W (Parke-Davis Pharmaceutical Res., Michigan)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 42  Issue： 26  Page： 5464-5474  Publication year： Dec. 30, 1999 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： nitrogen heterocyclic compound ,...
Semi thesaurus term： PD-153035 ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=00A0225185&from=J-GLOBAL&jstjournalNo=D0102A") }}

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Pyrimidines  (CF07103W)

Substance index (30)： 2-[[6-(3-Methylanilino)-4-pyrimidinyl]amino]ethanol ,  PD-153035 ,  PD-158780 ,  N-(3-Bromophenyl)-1H-imidazo[4,5-g]quinazolin-8-amine ,  5-[(3-Bromophenyl)amino]-1,6,8-triaza-1H-benz[f]indene ,  N-(3-Bromophenyl)-1H-pyrazolo[4,3-g]quinazolin-5-amine ,  N-Phenyl-5H-pyrimido[5,4-b]indole-4-amine ,  N-(3-Bromophenyl)-5H-pyrimido[5,4-b]indole-4-amine ,  N-(3-Bromophenyl)-5-methyl-5H-pyrimido[5,4-b]indole-4-amine ,  N-(Benzyl)-5H-pyrimido[5,4-b]indole-4-amine ,  N-(3-Bromophenyl)-9H-pyrimido[4,5-b]indole-4-amine ,  N-(3-Bromophenyl)-9-methyl-9H-pyrimido[4,5-b]indole-4-amine ,  N-(3-Bromophenyl)-9-[2-(diethylamino)ethyl]-9H-pyrimido[4,5-b]indole-4-amine ,  N-(3-Bromophenyl)-2-methyl-9H-pyrimido[4,5-b]indole-4-amine ,  N-(3-Bromophenyl)[1]benzothieno[3,2-d]pyrimidine-4-amine ,  N-Phenyl-8-nitro[1]benzothieno[3,2-d]pyrimidine-4-amine ,  N-(3-Methylphenyl)-8-nitro[1]benzothieno[3,2-d]pyrimidine-4-amine ,  N-(3-Bromophenyl)-8-nitro[1]benzothieno[3,2-d]pyrimidine-4-amine ,  N-Phenyl[1]benzothieno[3,2-d]pyrimidine-4,8-diamine ,  N-(3-Methylphenyl)[1]benzothieno[3,2-d]pyrimidine-4,8-diamine ,  N-[3-(Trifluoromethyl)phenyl][1]benzothieno[3,2-d]pyrimidine-4,8-diamine ,  N-(3-Bromophenyl)[1]benzothieno[3,2-d]pyrimidine-4,8-diamine ,  N-(3-Bromophenyl)-7-nitro[1]benzothieno[3,2-d]pyrimidine-4-amine ,  N-(3-Bromophenyl)[1]benzothieno[3,2-d]pyrimidine-4,7-diamine ,  N-(3-Bromophenyl)-8-fluoro[1]benzothieno[3,2-d]pyrimidine-4,7-diamine ,  N-(3-Bromophenyl)-N′-ethyl-8-fluoro[1]benzothieno[3,2-d]pyrimidine-4,7-diamine ,  N-(3-Chlorophenyl)pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4-amine ,  N-(3-Bromophenyl)pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4-amine ,  N-(3-Bromophenyl)-1,4,6-triaza-3,8-dithiacyclopenta[a]indene-7-amine ,  N-(3-Bromophenyl)benzofuro[3,2-d]pyrimidine-4-amine

Terms in the title (7)： チロシンキナーゼ阻害剤 ,  上皮成長因子受容体 ,  チロシンキナーゼ ,  阻害剤 ,  三環 ,  ピリミジン類 ,  インドール類