Art

J-GLOBAL ID：200902173807572346   Reference number：93A0537994

Cyclic Nucleotide Phosphodiesterase Inhibition by Imidazopyridines: Analogues of Sulmazole and Isomazole as Inhibitors of the cGMP Specific Phosphodiesterase.

イミダゾピリジン類による環状ヌクレオチドホスホジエステラーゼ阻害 cGMP特異的ホスホジエステラーゼ阻害剤としてのスルマゾール及びイソマゾールの類似体

Author (5)： COATES W J (SmithKline Beecham Pharmaceuticals, Hertfordshire, GBR) ,  CONNOLLY B (SmithKline Beecham Pharmaceuticals, Hertfordshire, GBR) ,  DHANAK D (SmithKline Beecham Pharmaceuticals, Hertfordshire, GBR) ,  FLYNN S T (SmithKline Beecham Pharmaceuticals, Hertfordshire, GBR) ,  WORBY A (SmithKline Beecham Pharmaceuticals, Hertfordshire, GBR)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 36  Issue： 10  Page： 1387-1392  Publication year： May. 14, 1993 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： sulmazole ,...

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JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Other condensed derivatives of pyridine  (CF07097Y)

Substance index (28)： Sulmazole ,  Isomazole ,  Zaprinast ,  2-(2-Methoxyphenyl)-1H-imidazo[4,5-b]pyridine ,  2-[2-Ethoxyphenyl]-1H-imidazo[4,5-b]pyridine ,  2-[2-Propoxyphenyl]-1H-imidazo[4,5-b]pyridine ,  2-[2-Butoxyphenyl]-1H-imidazo[4,5-b]pyridine ,  2-[2-(Pentyloxy)phenyl]-1H-imidazo[4,5-b]pyridine ,  2-[2-(Hexyloxy)phenyl]-1H-imidazo[4,5-b]pyridine ,  2-[2-(Isobutyloxy)phenyl]-1H-imidazo[4,5-b]pyridine ,  2-[2-(tert-Butyloxy)phenyl]-1H-imidazo[4,5-b]pyridine ,  2-[2-(Benzyloxy)phenyl]-1H-imidazo[4,5-b]pyridine ,  2-[2-(2-Hydroxyethoxy)phenyl]-1H-imidazo[4,5-b]pyridine ,  2-[2-(3-Hydroxypropoxy)phenyl]-1H-imidazo[4,5-b]pyridine ,  2-[2-(Propylthio)phenyl]-1H-imidazo[4,5-b]pyridine ,  2-[2-Nitrophenyl]-1H-imidazo[4,5-b]pyridine ,  2-[2-(3-Chloropropoxy)phenyl]-1H-imidazo[4,5-b]pyridine ,  2-[2-(Cyclopentyloxy)phenyl]-1H-imidazo[4,5-b]pyridine ,  2-[2-(Cyclopropylmethoxy)phenyl]-1H-imidazo[4,5-b]pyridine ,  3-[2-(1H-Imidazo[4,5-b]pyridin-2-yl)phenoxy]-N-methyl-1-propanamine ,  3-[2-(1H-Imidazo[4,5-b]pyridin-2-yl)phenoxy]-N,N-dimethyl-1-propanamine ,  2-(1H-Imidazo[4,5-b]pyridin-2-yl)aniline ,  2-(1H-Imidazo[4,5-b]pyridin-2-yl)-N-propylaniline ,  2-(1H-Imidazo[4,5-b]pyridin-2-yl)phenol ,  Acetic acid 2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl ester ,  2-(2-Propoxyphenyl)imidazo[1,2-a]pyrimidine ,  2-[2-(Pentyloxy)phenyl]-1H-imidazo[4,5-c]pyridine ,  2-(2-Methoxyphenyl)-1H-imidazo[4,5-c]pyridine

Terms in the title (7)： 環状ヌクレオチドホスホジエステラーゼ ,  阻害 ,  cGMP ,  ホスホジエステラーゼ阻害剤 ,  スルマゾール ,  イソマゾール ,  類似体